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@article{1331741,
author = {Mach, Lukáš and Konecny, Tomas and Helánová, Kateřina and Jaffe, Allan S. and Sorenson, Eric J. and Somers, Virend K. and Reeder, Guy S.},
article_location = {Heidelberg},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s13760-015-0596-8},
keywords = {Acute coronary syndrome; Neuromuscular disease; Amyotrophic lateral sclerosis; Troponin T},
language = {eng},
issn = {0300-9009},
journal = {Acta Neurologica Belgica},
title = {Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis},
url = {http://link.springer.com/article/10.1007/s13760-015-0596-8},
volume = {116},
year = {2016}
}
TY - JOUR
ID - 1331741
AU - Mach, Lukáš - Konecny, Tomas - Helánová, Kateřina - Jaffe, Allan S. - Sorenson, Eric J. - Somers, Virend K. - Reeder, Guy S.
PY - 2016
TI - Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis
JF - Acta Neurologica Belgica
VL - 116
IS - 4
SP - 557-564
EP - 557-564
PB - Springer Heidelberg
SN - 03009009
KW - Acute coronary syndrome
KW - Neuromuscular disease
KW - Amyotrophic lateral sclerosis
KW - Troponin T
UR - http://link.springer.com/article/10.1007/s13760-015-0596-8
N2 - Limited evidence suggests that specificity of cardiac troponin T (cTnT), a highly sensitive biomarker of myocardial injury, is reduced in patients with skeletal myopathies. Whether amyotrophic lateral sclerosis (ALS) the most common motor neuron disease could be also associated with abnormal plasma or serum cTnT levels remains unclear. Our objective was to assess cTnT levels in patients with ALS without known cTnT elevating conditions. Among ALS patients seen at our institution until 2012 we identified those who had their cTnT measured. Patients who suffered from conditions known to elevate cTnT were excluded. A case–control analysis comparing cTnT levels of these ALS patients to matched non-ALS controls fulfilling the same inclusion criteria was performed. We included 40 ALS patients of whom 27 (68 %) patients had a positive cTnT. In the control group (n = 40), 2 (5 %) tested as cTnT positive. Among the ALS patients who underwent cTnT evaluation on more occasions (n = 7; median followup = 1.08 years), 2 (29 %) patients tested positive during the initial measurement while 6 (86 %) of them had positive cTnT at the subsequent evaluations. ALS patients with increased cTnT had been diagnosed with ALS significantly earlier than those without the elevation. Our findings raise the possibility that ALS may cause cTnT elevations. Further studies are needed to confirm these findings, clarify the pathophysiological mechanism, and establish the significance of cTnT elevations in patients with ALS.
ER -
MACH, Lukáš, Tomas KONECNY, Kateřina HELÁNOVÁ, Allan S. JAFFE, Eric J. SORENSON, Virend K. SOMERS and Guy S. REEDER. Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis. \textit{Acta Neurologica Belgica}. Heidelberg: Springer Heidelberg, 2016, vol.~116, No~4, p.~557-564. ISSN~0300-9009. Available from: https://dx.doi.org/10.1007/s13760-015-0596-8.
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