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@article{1333713, author = {Sándor, Roman and Midlik, Adam and Šebrlová, Kristýna and Dovrtělová, Gabriela and Nosková, Kristýna and Juřica, Jan and Slaninová, Iva and Táborská, Eva and Peš, Ondřej}, article_location = {Amsterdam}, article_number = {"neuvedeno"}, doi = {http://dx.doi.org/10.1016/j.jpba.2016.01.024}, keywords = {benzophenanthridines; metabolites; rat liver microsomes; mass spectrometry; isolation}, language = {eng}, issn = {0731-7085}, journal = {Journal of Pharmaceutical and Biomedical Analysis}, title = {Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation}, url = {http://www.sciencedirect.com/science/article/pii/S0731708516300255}, volume = {121}, year = {2016} }
TY - JOUR ID - 1333713 AU - Sándor, Roman - Midlik, Adam - Šebrlová, Kristýna - Dovrtělová, Gabriela - Nosková, Kristýna - Juřica, Jan - Slaninová, Iva - Táborská, Eva - Peš, Ondřej PY - 2016 TI - Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation JF - Journal of Pharmaceutical and Biomedical Analysis VL - 121 IS - "neuvedeno" SP - 174-180 EP - 174-180 PB - Elsevier Science BV SN - 07317085 KW - benzophenanthridines KW - metabolites KW - rat liver microsomes KW - mass spectrometry KW - isolation UR - http://www.sciencedirect.com/science/article/pii/S0731708516300255 N2 - Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown. Reactions involved in transformation include single and/or double O-demethylation, demethylenation, reduction, and hydroxylation. Two metabolites, when isolated, purified and tested for toxicity, were found to be less toxic than the original compounds. ER -
SÁNDOR, Roman, Adam MIDLIK, Kristýna ŠEBRLOVÁ, Gabriela DOVRTĚLOVÁ, Kristýna NOSKOVÁ, Jan JUŘICA, Iva SLANINOVÁ, Eva TÁBORSKÁ and Ondřej PEŠ. Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation. \textit{Journal of Pharmaceutical and Biomedical Analysis}. Amsterdam: Elsevier Science BV, 2016, vol.~121, ''neuvedeno'', p.~174-180. ISSN~0731-7085. Available from: https://dx.doi.org/10.1016/j.jpba.2016.01.024.
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