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@article{1334100,
author = {Raudenská, Martina and Svobodová, Markéta and Gumulec, Jaromír and Fojtů, Michaela and Polanská, Hana and Balvan, Jan and Feith, Marek and Binková, Hana and Horakova, Zuzana and Kostřica, Rom and Kizek, René and Masařík, Michal},
article_location = {Dordrecht},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s13277-015-3755-x},
keywords = {Head and neck neoplasms; Biological markers; Prognosis; Tumour microenvironment; Metallothionein; Matrix metalloproteinase 9; Gene expression},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {Prognostic significance of the tumour-adjacent tissue in head and neck cancers},
volume = {36},
year = {2015}
}
TY - JOUR
ID - 1334100
AU - Raudenská, Martina - Svobodová, Markéta - Gumulec, Jaromír - Fojtů, Michaela - Polanská, Hana - Balvan, Jan - Feith, Marek - Binková, Hana - Horakova, Zuzana - Kostřica, Rom - Kizek, René - Masařík, Michal
PY - 2015
TI - Prognostic significance of the tumour-adjacent tissue in head and neck cancers
JF - Tumor Biology
VL - 36
IS - 12
SP - 9929-9939
EP - 9929-9939
PB - Springer
SN - 10104283
KW - Head and neck neoplasms
KW - Biological markers
KW - Prognosis
KW - Tumour microenvironment
KW - Metallothionein
KW - Matrix metalloproteinase 9
KW - Gene expression
N2 - Even with significant advances in operative skills and adjuvant therapies, the overall survival of patients suffering with head and neck squamous cancers (HNSCC) is unsatisfactory. Accordingly, no clinically useful prognostic biomarkers have been found yet for HNSCC. Many studies analysed the expression of potential markers in tumour tissues compared to adjacent tissues. Nevertheless, due to the sharing of the same microenvironment, adjacent tissues show molecular similarity to tumour tissues. Thus, gene expression patterns of 94 HNSCC tumorous tissues were compared with 31 adjacent tissues and with 10 tonsillectomy specimens of non-cancer individuals. The genes analysed at RNA level using quantitative RT-PCR and correlated with clinico-pathological conditions were as follows: EGF, EGFR, MKI67, BCL2, BAX, FOS, JUN, TP53, VEGF, FLT1, MMP2, MMP9, MT1A and MT2A. The elevated MT2A, BAX, EGF and JUN expression was associated with the influence of tumour cells on the rearrangement of healthy tissues, as well as a significant shift in the BAX/BCL2 ratio. Our investigation also indicated that adjacent tissues play an important role in cancerogenesis by releasing several tumour-supporting factors such as EGF. A gradual increase in the metallothionein expression, from the lowest one in tonsillectomy samples to the highest ones in tumour samples, suggests that MT expression might be tissue reaction to the presence of tumour cells. The results of this study confirmed the significance of metallothionein in tumori-genesis and gave evidences for its use as a potential HNSCC biomarker. Furthermore, this study highlighted the importance of histologically normal tumour-adjacent tissue in prediction of HNSCC progress.
ER -
RAUDENSKÁ, Martina, Markéta SVOBODOVÁ, Jaromír GUMULEC, Michaela FOJTŮ, Hana POLANSKÁ, Jan BALVAN, Marek FEITH, Hana BINKOVÁ, Zuzana HORAKOVA, Rom KOSTŘICA, René KIZEK and Michal MASAŘÍK. Prognostic significance of the tumour-adjacent tissue in head and neck cancers. \textit{Tumor Biology}. Dordrecht: Springer, 2015, vol.~36, No~12, p.~9929-9939. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-015-3755-x.
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