Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

ŠVACHOVÁ, Veronika; David PAVLIŇÁK; Lucy VOJTOVÁ; Milan ALBERTI; Josef JANČÁŘ a Pavel HYRŠL. Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects. 2014. ISBN 978-80-210-7159-9.

Základní údaje

Originální název

Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

Název česky

Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

Autoři

ŠVACHOVÁ, Veronika (203 Česká republika, garant); David PAVLIŇÁK (203 Česká republika, domácí); Lucy VOJTOVÁ (203 Česká republika); Milan ALBERTI (203 Česká republika, domácí); Josef JANČÁŘ (203 Česká republika) a Pavel HYRŠL (203 Česká republika, domácí)

Vydání

2014

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Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/14:00086539

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-210-7159-9

Klíčová slova česky

Elektrostatické zvlákňování; oxidovaná celulóza; želatina; baktericidní účinek

Klíčová slova anglicky

Elektrostatic spinning; oxidized cellulose; gelatine; baktericidal impact

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

This work is focused on the preparation of gelatin nanofibers modified with salts of oxidized cellulose. Gelatin is a biocompatible, biodegradable protein-based material with high absorption capacity, which is obtained by partial hydrolysis of natural protein - collagen. Oxidized cellulose and its salts are biocompatible as well, biodegradable and they have antibacterial and hemostatic effects. Electrospun novel nanofibers, combining properties of both gelatin and oxycellulose exhibited unique bactericide efficiency. Chemical composition of the fibers was studied by ATR-FTIR spectroscopy and EDX elemental analysis. Obtained results confirmed the presence of oxidized cellulose salt in prepared nanofibers. Diameter and morphology of nanofibers were determined by scanning electron microscopy (SEM). Bactericidal effect was examined by the method of chemical bioluminescence on modified bacterial strain of E. coli. This method proved complete mortality of E. coli in most of cases. Newly prepared material may have a potential application in surgery, regenerative medicine of soft tissue (burns) and in tissue engineering.

Česky

This work is focused on the preparation of gelatin nanofibers modified with salts of oxidized cellulose. Gelatin is a biocompatible, biodegradable protein-based material with high absorption capacity, which is obtained by partial hydrolysis of natural protein - collagen. Oxidized cellulose and its salts are biocompatible as well, biodegradable and they have antibacterial and hemostatic effects. Electrospun novel nanofibers, combining properties of both gelatin and oxycellulose exhibited unique bactericide efficiency. Chemical composition of the fibers was studied by ATR-FTIR spectroscopy and EDX elemental analysis. Obtained results confirmed the presence of oxidized cellulose salt in prepared nanofibers. Diameter and morphology of nanofibers were determined by scanning electron microscopy (SEM). Bactericidal effect was examined by the method of chemical bioluminescence on modified bacterial strain of E. coli. This method proved complete mortality of E. coli in most of cases. Newly prepared material may have a potential application in surgery, regenerative medicine of soft tissue (burns) and in tissue engineering.