Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

ŠVACHOVÁ, Veronika, David PAVLIŇÁK, Lucy VOJTOVÁ, Milan ALBERTI, Josef JANČÁŘ and Pavel HYRŠL. Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects. 2014. ISBN 978-80-210-7159-9.

Basic information

Original name

Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

Name in Czech

Gelatin Nanofibers Modified with Oxidized Cellulose with Significant Bactericidal Effects

Authors

ŠVACHOVÁ, Veronika (203 Czech Republic, guarantor), David PAVLIŇÁK (203 Czech Republic, belonging to the institution), Lucy VOJTOVÁ (203 Czech Republic), Milan ALBERTI (203 Czech Republic, belonging to the institution), Josef JANČÁŘ (203 Czech Republic) and Pavel HYRŠL (203 Czech Republic, belonging to the institution)

Edition

2014

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/14:00086539

Organization unit

Faculty of Science

ISBN

978-80-210-7159-9

Keywords (in Czech)

Elektrostatické zvlákňování; oxidovaná celulóza; želatina; baktericidní účinek

Keywords in English

Elektrostatic spinning; oxidized cellulose; gelatine; baktericidal impact

Tags

International impact, Reviewed

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Abstract

V originále

This work is focused on the preparation of gelatin nanofibers modified with salts of oxidized cellulose. Gelatin is a biocompatible, biodegradable protein-based material with high absorption capacity, which is obtained by partial hydrolysis of natural protein - collagen. Oxidized cellulose and its salts are biocompatible as well, biodegradable and they have antibacterial and hemostatic effects. Electrospun novel nanofibers, combining properties of both gelatin and oxycellulose exhibited unique bactericide efficiency. Chemical composition of the fibers was studied by ATR-FTIR spectroscopy and EDX elemental analysis. Obtained results confirmed the presence of oxidized cellulose salt in prepared nanofibers. Diameter and morphology of nanofibers were determined by scanning electron microscopy (SEM). Bactericidal effect was examined by the method of chemical bioluminescence on modified bacterial strain of E. coli. This method proved complete mortality of E. coli in most of cases. Newly prepared material may have a potential application in surgery, regenerative medicine of soft tissue (burns) and in tissue engineering.

In Czech

This work is focused on the preparation of gelatin nanofibers modified with salts of oxidized cellulose. Gelatin is a biocompatible, biodegradable protein-based material with high absorption capacity, which is obtained by partial hydrolysis of natural protein - collagen. Oxidized cellulose and its salts are biocompatible as well, biodegradable and they have antibacterial and hemostatic effects. Electrospun novel nanofibers, combining properties of both gelatin and oxycellulose exhibited unique bactericide efficiency. Chemical composition of the fibers was studied by ATR-FTIR spectroscopy and EDX elemental analysis. Obtained results confirmed the presence of oxidized cellulose salt in prepared nanofibers. Diameter and morphology of nanofibers were determined by scanning electron microscopy (SEM). Bactericidal effect was examined by the method of chemical bioluminescence on modified bacterial strain of E. coli. This method proved complete mortality of E. coli in most of cases. Newly prepared material may have a potential application in surgery, regenerative medicine of soft tissue (burns) and in tissue engineering.