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@article{1335888,
author = {Linzer, Petr and Filip, Michal and Jurek, Patrik and Šálek, Tomáš and Gajdoš, Miroslav and Jarkovský, Jiří and 3405¨, },
article_location = {Poznan},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.pjnns.2015.10.008},
keywords = {Creatine kinase; Interleukin-6; Lumbar interbody fusion; Minimally invasive approach; Myoglobin},
language = {eng},
issn = {0028-3843},
journal = {Neurologia i Neurochirurgia Polska},
title = {Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion},
volume = {50},
year = {2016}
}
TY - JOUR
ID - 1335888
AU - Linzer, Petr - Filip, Michal - Jurek, Patrik - Šálek, Tomáš - Gajdoš, Miroslav - Jarkovský, Jiří - 3405¨,
PY - 2016
TI - Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion
JF - Neurologia i Neurochirurgia Polska
VL - 50
IS - 1
SP - 16-23
EP - 16-23
PB - Termedia Publishing House LTD
SN - 00283843
KW - Creatine kinase
KW - Interleukin-6
KW - Lumbar interbody fusion
KW - Minimally invasive approach
KW - Myoglobin
N2 - Background: The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma. The measuring of suitable biochemical factors enables objective comparison of the invasiveness of spinal surgery procedures. Methods: Prospectively collected data on myoglobin, creatine kinase, interleukin-6, C-reactive protein levels and intensity of low back pain and radicular pain in one-level mini PLIF and open PLIF procedures were analysed. The mini PLIF and the open PLIF groups included 27 and 23 patients, respectively. The collection of blood samples and clinical data were performed preoperatively and on postoperative days 1, 3 and 7. The non-paired t-test was used for statistical evaluation. Results: We did not found any statistically significant differences of myoglobin and creatine kinase levels between the groups. In the open PLIF group the IL-6 levels were significantly higher than in the mini PLIF group on postoperative day 3. CRP levels showed significant lower stress response in favour of the mini PLIF group on postoperative days 3 and 7. Levels of post-op low back pain on day 3 were significantly lower in mini PLIF group. Also intensity of radicular pain on day 1 and 3 were lower also mini PLIF group. Conclusion: The extent of myonecrosis was comparable in both techniques. The analysis of the IL-6 and CRP levels showed significantly lower systemic inflammatory response in mini PLIF technique. The mini PLIF technique provides transiently lower postoperative pain levels.
ER -
LINZER, Petr, Michal FILIP, Patrik JUREK, Tomáš ŠÁLEK, Miroslav GAJDOŠ and Jiří JARKOVSKÝ. Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion. \textit{Neurologia i Neurochirurgia Polska}. Poznan: Termedia Publishing House LTD, 2016, vol.~50, No~1, p.~16-23. ISSN~0028-3843. Available from: https://dx.doi.org/10.1016/j.pjnns.2015.10.008.
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