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@article{1336105,
author = {Bányiová, Katarína and Čupr, Pavel and Kohoutek, Jiří},
article_location = {HEIDELBERG (GERMANY)},
article_number = {14},
doi = {http://dx.doi.org/10.1007/s11356-015-4252-x},
keywords = {Franz cell; Dermal exposure; Chlorotoluron; Pesticides; Ex vivo permeability coefficient; Dermal absorbed dose; Recommended reference dose; Human health risk assessment},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron},
url = {http://link.springer.com/article/10.1007%2Fs11356-015-4252-x},
volume = {22},
year = {2015}
}
TY - JOUR
ID - 1336105
AU - Bányiová, Katarína - Čupr, Pavel - Kohoutek, Jiří
PY - 2015
TI - An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron
JF - Environmental Science and Pollution Research
VL - 22
IS - 14
SP - 10713-10720
EP - 10713-10720
PB - Springer
SN - 09441344
KW - Franz cell
KW - Dermal exposure
KW - Chlorotoluron
KW - Pesticides
KW - Ex vivo permeability coefficient
KW - Dermal absorbed dose
KW - Recommended reference dose
KW - Human health risk assessment
UR - http://link.springer.com/article/10.1007%2Fs11356-015-4252-x
L2 - http://link.springer.com/article/10.1007%2Fs11356-015-4252-x
N2 - Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications.
ER -
BÁNYIOVÁ, Katarína, Pavel ČUPR a Jiří KOHOUTEK. An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron. \textit{Environmental Science and Pollution Research}. HEIDELBERG (GERMANY): Springer, roč.~22, č.~14, s.~10713-10720. ISSN~0944-1344. doi:10.1007/s11356-015-4252-x. 2015.
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