J 2015

An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron

BÁNYIOVÁ, Katarína, Pavel ČUPR and Jiří KOHOUTEK

Basic information

Original name

An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron

Authors

BÁNYIOVÁ, Katarína (703 Slovakia, belonging to the institution), Pavel ČUPR (203 Czech Republic, guarantor, belonging to the institution) and Jiří KOHOUTEK (203 Czech Republic, belonging to the institution)

Edition

Environmental Science and Pollution Research, HEIDELBERG (GERMANY), Springer, 2015, 0944-1344

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.760

RIV identification code

RIV/00216224:14310/15:00081592

Organization unit

Faculty of Science

UT WoS

000357344300033

Keywords in English

Franz cell; Dermal exposure; Chlorotoluron; Pesticides; Ex vivo permeability coefficient; Dermal absorbed dose; Recommended reference dose; Human health risk assessment

Tags

Tags

International impact, Reviewed
Změněno: 14/3/2016 14:28, Mgr. Michaela Hylsová, Ph.D.

Abstract

V originále

Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications.

Links

GA14-27941S, research and development project
Name: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici
Investor: Czech Science Foundation
LO1214, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)
Investor: Ministry of Education, Youth and Sports of the CR