Detailed Information on Publication Record
2015
An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron
BÁNYIOVÁ, Katarína, Pavel ČUPR and Jiří KOHOUTEKBasic information
Original name
An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron
Authors
BÁNYIOVÁ, Katarína (703 Slovakia, belonging to the institution), Pavel ČUPR (203 Czech Republic, guarantor, belonging to the institution) and Jiří KOHOUTEK (203 Czech Republic, belonging to the institution)
Edition
Environmental Science and Pollution Research, HEIDELBERG (GERMANY), Springer, 2015, 0944-1344
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30304 Public and environmental health
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.760
RIV identification code
RIV/00216224:14310/15:00081592
Organization unit
Faculty of Science
UT WoS
000357344300033
Keywords in English
Franz cell; Dermal exposure; Chlorotoluron; Pesticides; Ex vivo permeability coefficient; Dermal absorbed dose; Recommended reference dose; Human health risk assessment
Tags
International impact, Reviewed
Změněno: 14/3/2016 14:28, Mgr. Michaela Hylsová, Ph.D.
Abstract
V originále
Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications.
Links
GA14-27941S, research and development project |
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LO1214, research and development project |
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