BÁNYIOVÁ, Katarína, Pavel ČUPR and Jiří KOHOUTEK. An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron. Environmental Science and Pollution Research. HEIDELBERG (GERMANY): Springer, 2015, vol. 22, No 14, p. 10713-10720. ISSN 0944-1344. Available from: https://dx.doi.org/10.1007/s11356-015-4252-x. |
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@article{1336105, author = {Bányiová, Katarína and Čupr, Pavel and Kohoutek, Jiří}, article_location = {HEIDELBERG (GERMANY)}, article_number = {14}, doi = {http://dx.doi.org/10.1007/s11356-015-4252-x}, keywords = {Franz cell; Dermal exposure; Chlorotoluron; Pesticides; Ex vivo permeability coefficient; Dermal absorbed dose; Recommended reference dose; Human health risk assessment}, language = {eng}, issn = {0944-1344}, journal = {Environmental Science and Pollution Research}, title = {An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron}, url = {http://link.springer.com/article/10.1007%2Fs11356-015-4252-x}, volume = {22}, year = {2015} }
TY - JOUR ID - 1336105 AU - Bányiová, Katarína - Čupr, Pavel - Kohoutek, Jiří PY - 2015 TI - An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron JF - Environmental Science and Pollution Research VL - 22 IS - 14 SP - 10713-10720 EP - 10713-10720 PB - Springer SN - 09441344 KW - Franz cell KW - Dermal exposure KW - Chlorotoluron KW - Pesticides KW - Ex vivo permeability coefficient KW - Dermal absorbed dose KW - Recommended reference dose KW - Human health risk assessment UR - http://link.springer.com/article/10.1007%2Fs11356-015-4252-x L2 - http://link.springer.com/article/10.1007%2Fs11356-015-4252-x N2 - Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications. ER -
BÁNYIOVÁ, Katarína, Pavel ČUPR and Jiří KOHOUTEK. An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron. \textit{Environmental Science and Pollution Research}. HEIDELBERG (GERMANY): Springer, 2015, vol.~22, No~14, p.~10713-10720. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-015-4252-x.
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