| ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVA, Amrita BASU, Pavel BABICA, Lenka Svihalkova SINDLEROVA, Lukáš KUBALA and Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. Environmental Science and Technology. WASHINGTON, DC (USA): American Chemical Society, 2015, vol. 49, No 20, p. 12457-12464. ISSN 0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.5b02049. |
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@article{1336287,
author = {Adamovský, Ondřej and Moosová, Zdena and Pekarova, Michaela and Basu, Amrita and Babica, Pavel and Sindlerova, Lenka Svihalkova and Kubala, Lukáš and Bláha, Luděk},
article_location = {WASHINGTON, DC (USA)},
article_number = {20},
doi = {http://dx.doi.org/10.1021/acs.est.5b02049},
keywords = {NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; ANION TRANSPORTING POLYPEPTIDES; ACTIVATED PROTEIN-KINASE; MELANOMA-CELL INVASION; LIVER-TUMOR PROMOTION; NITRIC-OXIDE; SIGNALING PATHWAYS; IN-VITRO},
language = {eng},
issn = {0013-936X},
journal = {Environmental Science and Technology},
title = {Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin},
url = {http://pubs.acs.org/doi/10.1021/acs.est.5b02049},
volume = {49},
year = {2015}
}
TY - JOUR
ID - 1336287
AU - Adamovský, Ondřej - Moosová, Zdena - Pekarova, Michaela - Basu, Amrita - Babica, Pavel - Sindlerova, Lenka Svihalkova - Kubala, Lukáš - Bláha, Luděk
PY - 2015
TI - Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
JF - Environmental Science and Technology
VL - 49
IS - 20
SP - 12457-12464
EP - 12457-12464
PB - American Chemical Society
SN - 0013936X
KW - NF-KAPPA-B
KW - NECROSIS-FACTOR-ALPHA
KW - TOLL-LIKE RECEPTORS
KW - ANION TRANSPORTING POLYPEPTIDES
KW - ACTIVATED PROTEIN-KINASE
KW - MELANOMA-CELL INVASION
KW - LIVER-TUMOR PROMOTION
KW - NITRIC-OXIDE
KW - SIGNALING PATHWAYS
KW - IN-VITRO
UR - http://pubs.acs.org/doi/10.1021/acs.est.5b02049
L2 - http://pubs.acs.org/doi/10.1021/acs.est.5b02049
N2 - Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs.
ER -
ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVA, Amrita BASU, Pavel BABICA, Lenka Svihalkova SINDLEROVA, Lukáš KUBALA and Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. \textit{Environmental Science and Technology}. WASHINGTON, DC (USA): American Chemical Society, 2015, vol.~49, No~20, p.~12457-12464. ISSN~0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.5b02049.
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