ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVA, Amrita BASU, Pavel BABICA, Lenka Svihalkova SINDLEROVA, Lukáš KUBALA and Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. Environmental Science and Technology. WASHINGTON, DC (USA): American Chemical Society, 2015, vol. 49, No 20, p. 12457-12464. ISSN 0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.5b02049. |
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@article{1336287, author = {Adamovský, Ondřej and Moosová, Zdena and Pekarova, Michaela and Basu, Amrita and Babica, Pavel and Sindlerova, Lenka Svihalkova and Kubala, Lukáš and Bláha, Luděk}, article_location = {WASHINGTON, DC (USA)}, article_number = {20}, doi = {http://dx.doi.org/10.1021/acs.est.5b02049}, keywords = {NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; ANION TRANSPORTING POLYPEPTIDES; ACTIVATED PROTEIN-KINASE; MELANOMA-CELL INVASION; LIVER-TUMOR PROMOTION; NITRIC-OXIDE; SIGNALING PATHWAYS; IN-VITRO}, language = {eng}, issn = {0013-936X}, journal = {Environmental Science and Technology}, title = {Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin}, url = {http://pubs.acs.org/doi/10.1021/acs.est.5b02049}, volume = {49}, year = {2015} }
TY - JOUR ID - 1336287 AU - Adamovský, Ondřej - Moosová, Zdena - Pekarova, Michaela - Basu, Amrita - Babica, Pavel - Sindlerova, Lenka Svihalkova - Kubala, Lukáš - Bláha, Luděk PY - 2015 TI - Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin JF - Environmental Science and Technology VL - 49 IS - 20 SP - 12457-12464 EP - 12457-12464 PB - American Chemical Society SN - 0013936X KW - NF-KAPPA-B KW - NECROSIS-FACTOR-ALPHA KW - TOLL-LIKE RECEPTORS KW - ANION TRANSPORTING POLYPEPTIDES KW - ACTIVATED PROTEIN-KINASE KW - MELANOMA-CELL INVASION KW - LIVER-TUMOR PROMOTION KW - NITRIC-OXIDE KW - SIGNALING PATHWAYS KW - IN-VITRO UR - http://pubs.acs.org/doi/10.1021/acs.est.5b02049 L2 - http://pubs.acs.org/doi/10.1021/acs.est.5b02049 N2 - Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs. ER -
ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVA, Amrita BASU, Pavel BABICA, Lenka Svihalkova SINDLEROVA, Lukáš KUBALA and Luděk BLÁHA. Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin. \textit{Environmental Science and Technology}. WASHINGTON, DC (USA): American Chemical Society, 2015, vol.~49, No~20, p.~12457-12464. ISSN~0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.5b02049.
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