JANKOWSKA, Maja, Joerg FUCHS, Evelyn KLOCKE, Miloslava FOJTOVÁ, Pavla SOVÁKOVÁ, Jiří FAJKUS, Veit SCHUBERT and Andreas Manfred HOUBEN. Holokinetic centromeres and efficient telomere healing enable rapid karyotype evolution. Chromosoma. New York: Springer, 2015, vol. 124, No 4, p. 519-528. ISSN 0009-5915. doi:10.1007/s00412-015-0524-y.
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Basic information
Original name Holokinetic centromeres and efficient telomere healing enable rapid karyotype evolution
Authors JANKOWSKA, Maja (276 Germany), Joerg FUCHS (276 Germany), Evelyn KLOCKE (276 Germany), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Pavla SOVÁKOVÁ (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution), Veit SCHUBERT (276 Germany) and Andreas Manfred HOUBEN (276 Germany).
Edition Chromosoma, New York, Springer, 2015, 0009-5915.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.303
RIV identification code RIV/00216224:14740/15:00081618
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1007/s00412-015-0524-y
UT WoS 000365750700008
Keywords in English Chromosome fusion and fission; De novo telomere synthesis; Holocentric chromosome; Holocentric genome evolution; Luzula elegans
Tags podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 5. 4. 2016 16:29.
Abstract
Species with holocentric chromosomes are often characterized by a rapid karyotype evolution. In contrast to species with monocentric chromosomes where acentric fragments are lost during cell division, breakage of holocentric chromosomes creates fragments with normal centromere activity. To decipher the mechanism that allows holocentric species an accelerated karyotype evolution via chromosome breakage, we analyzed the chromosome complements of irradiated Luzula elegans plants. The resulting chromosomal fragments and rearranged chromosomes revealed holocentromere-typical CENH3 and histone H2AThr120ph signals as well as the same mitotic mobility like unfragmented chromosomes. Newly synthesized telomeres at break points become detectable 3 weeks after irradiation. The presence of active telomerase suggests a telomerase-based mechanism of chromosome healing. A successful transmission of holocentric chromosome fragments across different generations was found for most offspring of irradiated plants. Hence, a combination of holokinetic centromere activity and the fast formation of new telomeres at break points enables holocentric species a rapid karyotype evolution involving chromosome fissions and rearrangements.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
EE2.3.20.0189, research and development projectName: Rozvoj výzkumné excelence v oblasti evoluční cytogenomiky, epigenetiky a buněčné signalizace
GA13-06943S, research and development projectName: Strukturní a funkční komponenty rostlinných telomer
Investor: Czech Science Foundation
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