ŠTARHA, Pavel, Lucie HANOUSKOVÁ a Zdeněk TRÁVNÍČEK. Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line. Plos one. San Francisco: Public Library of Science, 2015, roč. 10, č. 11, s. "nestránkováno", 19 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0143871. |
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@article{1337158, author = {Štarha, Pavel and Hanousková, Lucie and Trávníček, Zdeněk}, article_location = {San Francisco}, article_number = {11}, doi = {http://dx.doi.org/10.1371/journal.pone.0143871}, keywords = {CRYSTAL-STRUCTURES; IN-VITRO; NAMI-A; RUTHENIUM; CYTOTOXICITY; LIGANDS; METALS; INTERCALATION; DERIVATIVES; DRUG}, language = {eng}, issn = {1932-6203}, journal = {Plos one}, title = {Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line}, url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143871}, volume = {10}, year = {2015} }
TY - JOUR ID - 1337158 AU - Štarha, Pavel - Hanousková, Lucie - Trávníček, Zdeněk PY - 2015 TI - Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line JF - Plos one VL - 10 IS - 11 SP - "nestránkováno" EP - "nestránkováno" PB - Public Library of Science SN - 19326203 KW - CRYSTAL-STRUCTURES KW - IN-VITRO KW - NAMI-A KW - RUTHENIUM KW - CYTOTOXICITY KW - LIGANDS KW - METALS KW - INTERCALATION KW - DERIVATIVES KW - DRUG UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143871 L2 - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143871 N2 - A series of organometallic half-sandwich dichloridoruthenium(II) complexes of the general formula [Ru(eta(6)-p-cym)(naza)Cl-2] (1-8; p-cym = p-cymene; naza = 7-azaindole or its derivatives) was synthesised and fully characterized by elemental analysis, mass spectrometry, and infrared and multinuclear NMR spectroscopy. A single-crystal X-ray structural analysis of [Ru(eta(6)-p-cym)(2Me4Claza)Cl-2] (6) revealed a typical piano-stool geometry with an N7-coordination mode of 2-methyl-4-chloro-7-azaindole (2Me4Claza). The complexes have been found to be inactive against human ovarian cancer cell line A2780 up to the highest applied concentration (IC50 > 50.0 mu M). An inactivity of the complexes is caused by their instability in water-containing solvents connected with a release of the naza N-donor ligand, as proved by the detailed H-1 NMR, mass spectrometry and fluorescence experiments. ER -
ŠTARHA, Pavel, Lucie HANOUSKOVÁ a Zdeněk TRÁVNÍČEK. Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line. \textit{Plos one}. San Francisco: Public Library of Science, 2015, roč.~10, č.~11, s.~''nestránkováno'', 19 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0143871.
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