The utility of -synuclein as biofluid marker in
neurodegenerative diseases: a systematic review of the
literature

J 2016

The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

SIMONSEN, Anja Hviid, Bea KUIPERIJ, Omar Mukhtar Ali EL-AGNAF, Sebastian ENGELBORGHS, Sanna-Kaisa HERUKKA et. al.

Basic information

Original name

The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

Authors

SIMONSEN, Anja Hviid (208 Denmark), Bea KUIPERIJ (528 Netherlands), Omar Mukhtar Ali EL-AGNAF (634 Qatar), Sebastian ENGELBORGHS (56 Belgium), Sanna-Kaisa HERUKKA (246 Finland), Lucilla PARNETTI (380 Italy), Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution), Eugeen VANMECHELEN (56 Belgium), Elisabeth KAPAKI (300 Greece), Marcel VERBEEK (528 Netherlands) and Brit MOLLENHAUER (276 Germany)

Edition

BIOMARKERS IN MEDICINE, LONDON, FUTURE MEDICINE LTD, 2016, 1752-0363

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.020

RIV identification code

RIV/00216224:14740/16:00089458

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.2217/BMM.14.105

UT WoS

000367011600004

Keywords in English

alpha-synuclein; biomarker; CSF; diagnosis; ELISA; Parkinson's disease

Abstract

V originále

The discovery of -synuclein (-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of -syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of -syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of -syn has yielded novel insights into the variety of -syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of -syn as biomarker. We also suggest future approaches to use of CSF -syn in neurodegenerative diseases.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

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Citovat

SIMONSEN, Anja Hviid, Bea KUIPERIJ, Omar Mukhtar Ali EL-AGNAF, Sebastian ENGELBORGHS, Sanna-Kaisa HERUKKA, Lucilla PARNETTI, Irena REKTOROVÁ, Eugeen VANMECHELEN, Elisabeth KAPAKI, Marcel VERBEEK and Brit MOLLENHAUER. The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature. BIOMARKERS IN MEDICINE. LONDON: FUTURE MEDICINE LTD, 2016, vol. 10, No 1, p. 19-34. ISSN 1752-0363. Available from: https://dx.doi.org/10.2217/BMM.14.105.

@article{1337320,
   author = {Simonsen, Anja Hviid and Kuiperij, Bea and ElandAgnaf, Omar Mukhtar Ali and Engelborghs, Sebastian and Herukka, SannaandKaisa and Parnetti, Lucilla and Rektorová, Irena and Vanmechelen, Eugeen and Kapaki, Elisabeth and Verbeek, Marcel and Mollenhauer, Brit},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.2217/BMM.14.105},
   keywords = {alpha-synuclein; biomarker; CSF; diagnosis; ELISA; Parkinson's disease},
   language = {eng},
   issn = {1752-0363},
   journal = {BIOMARKERS IN MEDICINE},
   title = {The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature},
   url = {http://www.futuremedicine.com/doi/10.2217/BMM.14.105},
   volume = {10},
   year = {2016}
}

TY  - JOUR
ID  - 1337320
AU  - Simonsen, Anja Hviid - Kuiperij, Bea - El-Agnaf, Omar Mukhtar Ali - Engelborghs, Sebastian - Herukka, Sanna-Kaisa - Parnetti, Lucilla - Rektorová, Irena - Vanmechelen, Eugeen - Kapaki, Elisabeth - Verbeek, Marcel - Mollenhauer, Brit
PY  - 2016
TI  - The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature
JF  - BIOMARKERS IN MEDICINE
VL  - 10
IS  - 1
SP  - 19-34
EP  - 19-34
PB  - FUTURE MEDICINE LTD
SN  - 17520363
KW  - alpha-synuclein
KW  - biomarker
KW  - CSF
KW  - diagnosis
KW  - ELISA
KW  - Parkinson's disease
UR  - http://www.futuremedicine.com/doi/10.2217/BMM.14.105
L2  - http://www.futuremedicine.com/doi/10.2217/BMM.14.105
N2  - The discovery of -synuclein (-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of -syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of -syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of -syn has yielded novel insights into the variety of -syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of -syn as biomarker. We also suggest future approaches to use of CSF -syn in neurodegenerative diseases.
ER  -

SIMONSEN, Anja Hviid, Bea KUIPERIJ, Omar Mukhtar Ali EL-AGNAF, Sebastian ENGELBORGHS, Sanna-Kaisa HERUKKA, Lucilla PARNETTI, Irena REKTOROVÁ, Eugeen VANMECHELEN, Elisabeth KAPAKI, Marcel VERBEEK and Brit MOLLENHAUER. The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature. \textit{BIOMARKERS IN MEDICINE}. LONDON: FUTURE MEDICINE LTD, 2016, vol.~10, No~1, p.~19-34. ISSN~1752-0363. Available from: https://dx.doi.org/10.2217/BMM.14.105.

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