Does the parasite-mediated selection drive the MHC class IIB
diversity in wild populations of European chub (Squalius
cephalus)?

J 2016

Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ and Andrea VETEŠNÍKOVÁ ŠIMKOVÁ

Basic information

Original name

Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?

Authors

SEIFERTOVÁ, Mária (703 Slovakia, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, guarantor, belonging to the institution) and Andrea VETEŠNÍKOVÁ ŠIMKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Parasitology Research, New York, Springer, 2016, 0932-0113

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.329

RIV identification code

RIV/00216224:14310/16:00087838

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s00436-015-4874-4

UT WoS

000372907300005

Keywords in English

Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites

Abstract

V originále

The genes of major histocompatibility complex (MHC) provide an excellent opportunity to study host-parasite relationships because they are expected to evolve in response to parasites, and variation in parasite communities. In this study, we investigated the potential role of parasite-mediated selection acting on MHC class IIB (DAB) genes in European chub (Squalius cephalus) natural populations. We found significant differences between populations in metazoan parasites, neutral and adaptive genetic diversities. The analyses based on pairwise data revealed that populations with dissimilar MHC allelic profiles were geographically distant populations with significantly different diversity in microsatellites and a dissimilar composition of parasite communities. The results from the generalized estimating equations method (GEE) on the level of individuals revealed that metazoan parasite load in European chub was influenced by the diversity of DAB alleles as well as by the diversity of neutral genetic markers and host traits reflecting condition and immunocompetence. The multivariate co-inertia analysis (COIA) showed specific associations between DAB alleles and parasite species. DAB1-like alleles were more involved in associations with ectoparasites, while DAB3-like alleles were positively associated with endoparasites which could suggest potential differences between DAB genes caused by different selection pressure. Our study revealed that parasite-mediated selection is not the only variable affecting MHC diversity in European chub; however, we strongly support the role of neutral processes as the main driver of DAB diversity across populations. In addition, our study contributes to the understanding of the evolution of MHC genes in wild living fish.

Links

GA524/07/0188, research and development project

Name: Úloha imunitní investice v kontextu kompromisů: imunoekologické studium vztahů mezi reprodukcí, imunitou a parazitizmem u sladkovodních ryb

Investor: Czech Science Foundation, The role of immune investment in the context of trade-offs: immuno-ecological study of the relationships among reproduction, immunity and parasitism

GBP505/12/G112, research and development project

Name: ECIP - Evropské centrum ichtyoparazitologie

Investor: Czech Science Foundation

Citovat

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ and Andrea VETEŠNÍKOVÁ ŠIMKOVÁ. Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)? Parasitology Research. New York: Springer, 2016, vol. 115, No 4, p. 1401-1415. ISSN 0932-0113. Available from: https://dx.doi.org/10.1007/s00436-015-4874-4.

@article{1338650,
   author = {Seifertová, Mária and Jarkovský, Jiří and Vetešníková Šimková, Andrea},
   article_location = {New York},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00436-015-4874-4},
   keywords = {Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites},
   language = {eng},
   issn = {0932-0113},
   journal = {Parasitology Research},
   title = {Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?},
   volume = {115},
   year = {2016}
}

TY  - JOUR
ID  - 1338650
AU  - Seifertová, Mária - Jarkovský, Jiří - Vetešníková Šimková, Andrea
PY  - 2016
TI  - Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?
JF  - Parasitology Research
VL  - 115
IS  - 4
SP  - 1401-1415
EP  - 1401-1415
PB  - Springer
SN  - 09320113
KW  - Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites
N2  - The genes of major histocompatibility complex (MHC) provide an excellent opportunity to study host-parasite relationships because they are expected to evolve in response to parasites, and variation in parasite communities. In this study, we investigated the potential role of parasite-mediated selection acting on MHC class IIB (DAB) genes in European chub (Squalius cephalus) natural populations. We found significant differences between populations in metazoan parasites, neutral and adaptive genetic diversities. The analyses based on pairwise data revealed that populations with dissimilar MHC allelic profiles were geographically distant populations with significantly different diversity in microsatellites and a dissimilar composition of parasite communities. The results from the generalized estimating equations method (GEE) on the level of individuals revealed that metazoan parasite load in European chub was influenced by the diversity of DAB alleles as well as by the diversity of neutral genetic markers and host traits reflecting condition and immunocompetence. The multivariate co-inertia analysis (COIA) showed specific associations between DAB alleles and parasite species. DAB1-like alleles were more involved in associations with ectoparasites, while DAB3-like alleles were positively associated with endoparasites which could suggest potential differences between DAB genes caused by different selection pressure. Our study revealed that parasite-mediated selection is not the only variable affecting MHC diversity in European chub; however, we strongly support the role of neutral processes as the main driver of DAB diversity across populations. In addition, our study contributes to the understanding of the evolution of MHC genes in wild living fish.
ER  -

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ and Andrea VETEŠNÍKOVÁ ŠIMKOVÁ. Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)? \textit{Parasitology Research}. New York: Springer, 2016, vol.~115, No~4, p.~1401-1415. ISSN~0932-0113. Available from: https://dx.doi.org/10.1007/s00436-015-4874-4.

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