Alkaline phosphatase in stem cells

J 2015

Alkaline phosphatase in stem cells

ŠTEFKOVÁ, Kateřina, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK

Basic information

Original name

Alkaline phosphatase in stem cells

Authors

ŠTEFKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Stem Cells International, New York, Hindawi Publishing Corporation, 2015, 1687-966X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.687

RIV identification code

RIV/00216224:14310/15:00086949

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1155/2015/628368

UT WoS

000350163700001

Keywords in English

alkaline phosphatase; stem cell; MSC; ESC

Abstract

V originále

Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.

Links

EE2.3.20.0180, research and development project

Name: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny

EE2.3.20.0185, research and development project

Name: Centrum analýz a modelování tkání a orgánů

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

Citovat

ŠTEFKOVÁ, Kateřina, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK. Alkaline phosphatase in stem cells. Stem Cells International. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 02, p. "nestrankovano", 11 pp. ISSN 1687-966X. Available from: https://dx.doi.org/10.1155/2015/628368.

@article{1338721,
   author = {Štefková, Kateřina and Procházková, Jiřina and Pacherník, Jiří},
   article_location = {New York},
   article_number = {02},
   doi = {http://dx.doi.org/10.1155/2015/628368},
   keywords = {alkaline phosphatase; stem cell; MSC; ESC},
   language = {eng},
   issn = {1687-966X},
   journal = {Stem Cells International},
   title = {Alkaline phosphatase in stem cells},
   url = {http://dx.doi.org/10.1155/2015/628368},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1338721
AU  - Štefková, Kateřina - Procházková, Jiřina - Pacherník, Jiří
PY  - 2015
TI  - Alkaline phosphatase in stem cells
JF  - Stem Cells International
VL  - 2015
IS  - 02
SP  - "nestrankovano"
EP  - "nestrankovano"
PB  - Hindawi Publishing Corporation
SN  - 1687966X
KW  - alkaline phosphatase
KW  - stem cell
KW  - MSC
KW  - ESC
UR  - http://dx.doi.org/10.1155/2015/628368
L2  - http://dx.doi.org/10.1155/2015/628368
N2  - Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.
ER  -

ŠTEFKOVÁ, Kateřina, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK. Alkaline phosphatase in stem cells. \textit{Stem Cells International}. New York: Hindawi Publishing Corporation, 2015, vol.~2015, No~02, p.~''nestrankovano'', 11 pp. ISSN~1687-966X. Available from: https://dx.doi.org/10.1155/2015/628368.

Detailed Information on Publication Record