Alkaline phosphatase in stem cells

ŠTEFKOVÁ, Kateřina, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK. Alkaline phosphatase in stem cells. Stem Cells International. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 02, p. "nestrankovano", 11 pp. ISSN 1687-966X. Available from: https://dx.doi.org/10.1155/2015/628368.

Basic information

• Original name: Alkaline phosphatase in stem cells
• Authors: ŠTEFKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Stem Cells International, New York, Hindawi Publishing Corporation, 2015, 1687-966X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.687
• RIV identification code: RIV/00216224:14310/15:00086949
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1155/2015/628368
• UT WoS: 000350163700001
• Keywords in English: alkaline phosphatase; stem cell; MSC; ESC
• Tags: AKR, EL OK, rivok
• Tags: International impact, Reviewed

Abstract

Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.

Links

• EE2.3.20.0180, research and development project: Name: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny
• EE2.3.20.0185, research and development project: Name: Centrum analýz a modelování tkání a orgánů
• MSM0021622430, plan (intention): Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies