Analysis of Heritability and Shared Heritability Based on
Genome-Wide Association Studies for 13 Cancer Types

SAMPSON, Joshua N., William A. WHEELER, Meredith YEAGER, Orestis PANAGIOTOU, Zhaoming WANG, Sonja I. BERNDT, Qing LAN, Christian C. ABNET, Laufey T. AMUNDADOTTIR, Jonine D. FIGUEROA, Maria Teresa LANDI, Lisa MIRABELLO, Sharon A. SAVAGE, Philip R. TAYLOR, Immaculata DEVIVO, Katherine A. MCGLYNN, Mark P. PURDUE, Preetha RAJARAMAN, Hans-Olov ADAMI, Anders AHLBOM, Demetrius ALBANES, Maria Fernanda AMARY, She-Juan AN, Ulrika ANDERSSON, Gerald Jr. ANDRIOLE, Irene L. ANDRULIS, Emanuele ANGELUCCI, Stephen M. ANSELL, Cecilia ARICI, Bruce K. ARMSTRONG, Alan A. ARSLAN, Melissa A. AUSTIN, Dalsu BARIS, Donald A. BARKAUSKAS, Bryan A. BASSIG, Nikolaus BECKER, Yolanda BENAVENTE, Simone BENHAMOU, Christine BERG, David VAN DEN BERG, Leslie BERNSTEIN, Kimberly A. BERTRAND, Brenda M. BIRMANN, Amanda BLACK, Heiner BOEING, Paolo BOFFETTA, Marie-Christine BOUTRON-RUAULT, Paige M. BRACCI, Louise BRINTON, Angela R. BROOKS-WILSON, H. Bas BUENO-DE-MESQUITA, Laurie BURDETT, Julie BURING, Mary Ann BUTLER, Qiuyin CAI, Geraldine CANCEL-TASSIN, Federico CANZIAN, Alfredo CARRATO, Tania CARREON, Angela CARTA, John K.C. CHAN, Ellen T. CHANG, Gee-Chen CHANG, I-Shou CHANG, Jiang CHANG, Jenny CHANG-CLAUDE, Chien-Jen CHEN, Chin-Yi CHEN, Chu CHEN, Chung-Hsing CHEN, Constance CHEN, Hongyan CHEN, Kexin CHEN, Kuan-Yu CHEN, Kun-Chieh CHEN, Ying CHEN, Ying-Hsiang CHEN, Yi-Song CHEN, Yuh-Min CHEN, Li-Hsin CHIEN, Maria-Dolores CHIRLAQUE, Jin Eun CHOI, Yi Young CHOI, Wong-Ho CHOW, Charles C. CHUNG, Jacqueline CLAVEL, Franoise CLAVEL-CHAPELON, Pierluigi COCCO, Joanne S. COLT, Eva COMPERAT, Lucia CONDE, Joseph M. CONNORS, David CONTI, Victoria K. CORTESSIS, Michelle COTTERCHIO, Wendy COZEN, Simon CROUCH, Marta CROUS-BOU, Olivier CUSSENOT, Faith G. DAVIS, Ti DING, W. Ryan DIVER, Miren DORRONSORO, Laure DOSSUS, Eric J. DUELL, Maria Grazia ENNAS, Ralph L. ERICKSON, Maria FEYCHTING, Adrienne M. FLANAGAN, Lenka FORETOVÁ, Joseph F. Jr. FRAUMENI, Neal D. FREEDMAN, Laura E. Beane FREEMAN, Charles FUCHS, Manuela GAGO-DOMINGUEZ, Steven GALLINGER, Yu-Tang GAO, Susan M. GAPSTUR, Montserrat GARCIA-CLOSAS, Reina GARCIA-CLOSAS, Randy D. GASCOYNE, Julie GASTIER-FOSTER, Mia M. GAUDET, J. Michael GAZIANO, Carol GIFFEN, Graham G. GILES, Edward GIOVANNUCCI, Bengt GLIMELIUS, Michael GOGGINS, Nalan GOKGOZ, Alisa M. GOLDSTEIN, Richard GORLICK, Myron GROSS, Robert III GRUBB, Jian GU, Peng GUAN, Marc GUNTER, Huan GUO, Thomas M. HABERMANN, Christopher A. HAIMAN, Dina HALAI, Goran HALLMANS, Manal HASSAN, Claudia HATTINGER, Qincheng HE, Xingzhou HE, Kathy HELZLSOUER, Brian HENDERSON, Roger HENRIKSSON, Henrik HJALGRIM, Judith HOFFMAN-BOLTON, Chancellor HOHENSEE, Theodore R. HOLFORD, Elizabeth A. HOLLY, Yun-Chul HONG, Robert N. HOOVER, Pamela L. HORN-ROSS, G.M. Monawar HOSAIN, H. Dean HOSGOOD, Chin-Fu HSIAO, Nan HU, Wei HU, Zhibin HU, Ming-Shyan HUANG, Jose-Maria HUERTA, Jen-Yu HUNG, Amy HUTCHINSON, Peter D. INSKIP, Rebecca D. JACKSON, Eric J. JACOBS, Mazda JENAB, Hyo-Sung JEON, Bu-Tian JI, Guangfu JIN, Li JIN, Christoffer JOHANSEN, Alison JOHNSON, Yoo Jin JUNG, Rudolph KAAKS, Aruna KAMINENI, Eleanor KANE, Cang Hyan KANG, Margaret R. KARAGAS, Rachel S. KELLY, Kay-Tee KHAW, Christopher KIM, Hee Nam KIM, Jin Hee KIM, Jun Suk KIM, Yeul Hong KIM, Young Tae KIM, Young Chul KIM, Cari M. KITAHARA, Alison P. KLEIN, Robert J. KLEIN, Manolis KOGEVINAS, Takashi KOHNO, Laurence N. KOLONEL, Charles KOOPERBERG, Anne KRICKER, Vittorio KROGH, Hideo KUNITOH, Robert C. KURTZ, Sun-Seog KWEON, Andrea LACROIX, Charles LAWRENCE, Fernando LECANDA, Victor Ho Fun LEE, Donghui LI, Haixin LI, Jihua LI, Yao-Jen LI, Yyqing LI, Linda M. LIAO, Mark LIEBOW, Tracy LIGHTFOOT, Wei-Yen LIM, Chien-Chung LIN, Dongxin LIN, Sasa LINDSTROM, Martha S. LINET, Brian K. LINK, Chenwei LIU, Jianjun LIU, Li LIU, Boerje LJUNGBERG, Josep LLORETA, Simonetta DI LOLLO, Daru LU, Eiluv LUND, Nuria MALATS, Satu MANNISTO, Loic LE MARCHAND, Neyssa MARINA, Giovanna MASALA, Giuseppe MASTRANGELO, Keitaro MATSUO, Marc MAYNADIE, James MCKAY, Roberta MCKEAN-COWDIN, Mads MELBYE, Beatrice S. MELIN, Dominique S. MICHAUD, Tetsuya MITSUDOMI, Alain MONNEREAU, Rebecca MONTALVAN, Lee E. MOORE, Lotte Maxild MORTENSEN, Alexandra NIETERS, Kari E. NORTH, Anne J. NOVAK, Ann L. OBERG, Kenneth OFFIT, In-Jae OH, Sara H. OLSON, Domenico PALLI, William PAO, In Kyu PARK, Jae Yong PARK, Kyong Hwa PARK, Ana PATINO-GARCIA, Sofia PAVANELLO, Petra H.M. PEETERS, Reury-Perng PERNG, Ulrike PETERS, Gloria M. PETERSEN, Piero PICCI, Malcolm C. PIKE, Stefano PORRU, Jennifer PRESCOTT, Ludmila PROKUNINA-OLSSON, Biyun QIAN, You-Lin QIAO, Marco RAIS, Elio RIBOLI, Jacques RIBY, Harvey A. RISCH, Cosmeri RIZZATO, Rebecca RODABOUGH, Eve ROMAN, Morgan ROUPRET, Avima M. RUDER, Silvia de SANJOSE, Ghislaine SCELO, Alan SCHNED, Fredrick SCHUMACHER, Kendra SCHWARTZ, Molly SCHWENN, Katia SCOTLANDI, Adeline SEOW, Consol SERRA, Massimo SERRA, Howard D. SESSO, Veronica Wendy SETIAWAN, Gianluca SEVERI, Richard K. SEVERSON, Tait D. SHANAFELT, Hongbing SHEN, Wei SHEN, Min-Ho SHIN, Kouya SHIRAISHI, Xiao-Ou SHU, Afshan SIDDIQ, Luis SIERRASESUMAGA, Alan Dart Loon SIHOE, Christine F. SKIBOLA, Alex SMITH, Martyn T. SMITH, Melissa C. SOUTHEY, John J. SPINELLI, Anthony STAINES, Meir STAMPFER, Marianna C. STERN, Victoria L. STEVENS, Rachael S. STOLZENBERG-SOLOMON, Jian SU, Wu-Chou SU, Malin SUND, Jae Sook SUNG, Sook Whan SUNG, Wen TAN, Wei TANG, Adonina TARDON, David THOMAS, Carrie A. THOMPSON, Lesley F. TINKER, Roberto TIRABOSCO, Anne TJONNELAND, Ruth C. TRAVIS, Dimitrios TRICHOPOULOS, Fang-Yu TSAI, Ying-Huang TSAI, Margaret TUCKER, Jenny TURNER, Claire M. VAJDIC, Roel C. H. VERMEULEN, Danylo J. VILLANO, Paolo VINEIS, Jarmo VIRTAMO, Kala VISVANATHAN, Jean WACTAWSKI-WENDE, Chaoyu WANG, Chih-Liang WANG, Jiu-Cun WANG, Junwen WANG, Fusheng WEI, Elisabete WEIDERPASS, George J. WEINER, Stephanie WEINSTEIN, Nicolas WENTZENSEN, Emily WHITE, Thomas E. WITZIG, Brian M. WOLPIN, Maria Pik WONG, Chen WU, Guoping WU, Junjie WU, Tangchun WU, Wei WU, Xifeng WU, Yi-Long WU, Jay S. WUNDER, Yong-Bing XIANG, Jun XU, Ping XU, Pan-Chyr YANG, Tsung-Ying YANG, Yuanqing YE, Zhihua YIN, Jun YOKOTA, Ho-ll YOON, Chong-Jen YU, Herbert YU, Kai YU, Jian-Min YUAN, Andrew ZELENETZ, Anne ZELENIUCH-JACQUOTTE, Xu-Chao ZHANG, Yawei ZHANG, Xueying ZHAO, Zhenhong ZHAO, Hong ZHENG, Tongzhang ZHENG, Wei ZHENG, Baosen ZHOU, Meng ZHU, Mariagrazia ZUCCA, Simina M. BOCA, James R. CERHAN, Giovanni M. FERRI, Patricia HARTGE, Chao Agnes HSIUNG, Corrado MAGNANI, Lucia MILIGI, Lindsay M. MORTON, Karin E. SMEDBY, Lauren R. TERAS, Joseph VIJAI, Sophia S. WANG, Paul BRENNAN, Neil E. CAPORASO, David J. HUNTER, Peter KRAFT, Nathaniel ROTHMAN, Debra T. SILVERMAN, Susan L. SLAGER, Stephen J. CHANOCK and Nilanjan CHATTERJEE. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. CARY: OXFORD UNIV PRESS INC, 2015, vol. 107, No 12, p. 1-11. ISSN 0027-8874. Available from: https://dx.doi.org/10.1093/jnci/djv279.

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@article{1340135,
   author = {Sampson, Joshua N. and Wheeler, William A. and Yeager, Meredith and Panagiotou, Orestis and Wang, Zhaoming and Berndt, Sonja I. and Lan, Qing and Abnet, Christian C. and Amundadottir, Laufey T. and Figueroa, Jonine D. and Landi, Maria Teresa and Mirabello, Lisa and Savage, Sharon A. and Taylor, Philip R. and DeVivo, Immaculata and McGlynn, Katherine A. and Purdue, Mark P. and Rajaraman, Preetha and Adami, HansandOlov and Ahlbom, Anders and Albanes, Demetrius and Amary, Maria Fernanda and An, SheandJuan and Andersson, Ulrika and Andriole, Gerald Jr. and Andrulis, Irene L. and Angelucci, Emanuele and Ansell, Stephen M. and Arici, Cecilia and Armstrong, Bruce K. and Arslan, Alan A. and Austin, Melissa A. and Baris, Dalsu and Barkauskas, Donald A. and Bassig, Bryan A. and Becker, Nikolaus and Benavente, Yolanda and Benhamou, Simone and Berg, Christine and Van Den Berg, David and Bernstein, Leslie and Bertrand, Kimberly A. and Birmann, Brenda M. and Black, Amanda and Boeing, Heiner and Boffetta, Paolo and BoutronandRuault, MarieandChristine and Bracci, Paige M. and Brinton, Louise and BrooksandWilson, Angela R. and BuenoandDeandMesquita, H. Bas and Burdett, Laurie and Buring, Julie and Butler, Mary Ann and Cai, Qiuyin and CancelandTassin, Geraldine and Canzian, Federico and Carrato, Alfredo and Carreon, Tania and Carta, Angela and Chan, John K.C. and Chang, Ellen T. and Chang, GeeandChen and Chang, IandShou and Chang, Jiang and ChangandClaude, Jenny and Chen, ChienandJen and Chen, ChinandYi and Chen, Chu and Chen, ChungandHsing and Chen, Constance and Chen, Hongyan and Chen, Kexin and Chen, KuanandYu and Chen, KunandChieh and Chen, Ying and Chen, YingandHsiang and Chen, YiandSong and Chen, YuhandMin and Chien, LiandHsin and Chirlaque, MariaandDolores and Choi, Jin Eun and Choi, Yi Young and Chow, WongandHo and Chung, Charles C. and Clavel, Jacqueline and ClavelandChapelon, Franoise and Cocco, Pierluigi and Colt, Joanne S. and Comperat, Eva and Conde, Lucia and Connors, Joseph M. and Conti, David and Cortessis, Victoria K. and Cotterchio, Michelle and Cozen, Wendy and Crouch, Simon and CrousandBou, Marta and Cussenot, Olivier and Davis, Faith G. and Ding, Ti and Diver, W. Ryan and Dorronsoro, Miren and Dossus, Laure and Duell, Eric J. and Ennas, Maria Grazia and Erickson, Ralph L. and Feychting, Maria and Flanagan, Adrienne M. and Foretová, Lenka and Fraumeni, Joseph F. Jr. and Freedman, Neal D. and Freeman, Laura E. Beane and Fuchs, Charles and GagoandDominguez, Manuela and Gallinger, Steven and Gao, YuandTang and Gapstur, Susan M. and GarciaandClosas, Montserrat and GarciaandClosas, Reina and Gascoyne, Randy D. and GastierandFoster, Julie and Gaudet, Mia M. and Gaziano, J. Michael and Giffen, Carol and Giles, Graham G. and Giovannucci, Edward and Glimelius, Bengt and Goggins, Michael and Gokgoz, Nalan and Goldstein, Alisa M. and Gorlick, Richard and Gross, Myron and Grubb, Robert III and Gu, Jian and Guan, Peng and Gunter, Marc and Guo, Huan and Habermann, Thomas M. and Haiman, Christopher A. and Halai, Dina and Hallmans, Goran and Hassan, Manal and Hattinger, Claudia and He, Qincheng and He, Xingzhou and Helzlsouer, Kathy and Henderson, Brian and Henriksson, Roger and Hjalgrim, Henrik and HoffmanandBolton, Judith and Hohensee, Chancellor and Holford, Theodore R. and Holly, Elizabeth A. and Hong, YunandChul and Hoover, Robert N. and HornandRoss, Pamela L. and Hosain, G.M. Monawar and Hosgood, H. Dean and Hsiao, ChinandFu and Hu, Nan and Hu, Wei and Hu, Zhibin and Huang, MingandShyan and Huerta, JoseandMaria and Hung, JenandYu and Hutchinson, Amy and Inskip, Peter D. and Jackson, Rebecca D. and Jacobs, Eric J. and Jenab, Mazda and Jeon, HyoandSung and Ji, BuandTian and Jin, Guangfu and Jin, Li and Johansen, Christoffer and Johnson, Alison and Jung, Yoo Jin and Kaaks, Rudolph and Kamineni, Aruna and Kane, Eleanor and Kang, Cang Hyan and Karagas, Margaret R. and Kelly, Rachel S. et al.},
   article_location = {CARY},
   article_number = {12},
   doi = {http://dx.doi.org/10.1093/jnci/djv279},
   keywords = {MULTIPLE SUSCEPTIBILITY LOCI; LUNG-CANCER; FAMILIAL RISK; PANCREATIC-CANCER; SWEDEN; INDIVIDUALS; MUTATIONS; RELATIVES; LYMPHOMA; DATABASE},
   language = {eng},
   issn = {0027-8874},
   journal = {JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE},
   title = {Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types},
   volume = {107},
   year = {2015}
}

SAMPSON, Joshua N., William A. WHEELER, Meredith YEAGER, Orestis PANAGIOTOU, Zhaoming WANG, Sonja I. BERNDT, Qing LAN, Christian C. ABNET, Laufey T. AMUNDADOTTIR, Jonine D. FIGUEROA, Maria Teresa LANDI, Lisa MIRABELLO, Sharon A. SAVAGE, Philip R. TAYLOR, Immaculata DEVIVO, Katherine A. MCGLYNN, Mark P. PURDUE, Preetha RAJARAMAN, Hans-Olov ADAMI, Anders AHLBOM, Demetrius ALBANES, Maria Fernanda AMARY, She-Juan AN, Ulrika ANDERSSON, Gerald Jr. ANDRIOLE, Irene L. ANDRULIS, Emanuele ANGELUCCI, Stephen M. ANSELL, Cecilia ARICI, Bruce K. ARMSTRONG, Alan A. ARSLAN, Melissa A. AUSTIN, Dalsu BARIS, Donald A. BARKAUSKAS, Bryan A. BASSIG, Nikolaus BECKER, Yolanda BENAVENTE, Simone BENHAMOU, Christine BERG, David VAN DEN BERG, Leslie BERNSTEIN, Kimberly A. BERTRAND, Brenda M. BIRMANN, Amanda BLACK, Heiner BOEING, Paolo BOFFETTA, Marie-Christine BOUTRON-RUAULT, Paige M. BRACCI, Louise BRINTON, Angela R. BROOKS-WILSON, H. Bas BUENO-DE-MESQUITA, Laurie BURDETT, Julie BURING, Mary Ann BUTLER, Qiuyin CAI, Geraldine CANCEL-TASSIN, Federico CANZIAN, Alfredo CARRATO, Tania CARREON, Angela CARTA, John K.C. CHAN, Ellen T. CHANG, Gee-Chen CHANG, I-Shou CHANG, Jiang CHANG, Jenny CHANG-CLAUDE, Chien-Jen CHEN, Chin-Yi CHEN, Chu CHEN, Chung-Hsing CHEN, Constance CHEN, Hongyan CHEN, Kexin CHEN, Kuan-Yu CHEN, Kun-Chieh CHEN, Ying CHEN, Ying-Hsiang CHEN, Yi-Song CHEN, Yuh-Min CHEN, Li-Hsin CHIEN, Maria-Dolores CHIRLAQUE, Jin Eun CHOI, Yi Young CHOI, Wong-Ho CHOW, Charles C. CHUNG, Jacqueline CLAVEL, Franoise CLAVEL-CHAPELON, Pierluigi COCCO, Joanne S. COLT, Eva COMPERAT, Lucia CONDE, Joseph M. CONNORS, David CONTI, Victoria K. CORTESSIS, Michelle COTTERCHIO, Wendy COZEN, Simon CROUCH, Marta CROUS-BOU, Olivier CUSSENOT, Faith G. DAVIS, Ti DING, W. Ryan DIVER, Miren DORRONSORO, Laure DOSSUS, Eric J. DUELL, Maria Grazia ENNAS, Ralph L. ERICKSON, Maria FEYCHTING, Adrienne M. FLANAGAN, Lenka FORETOVÁ, Joseph F. Jr. FRAUMENI, Neal D. FREEDMAN, Laura E. Beane FREEMAN, Charles FUCHS, Manuela GAGO-DOMINGUEZ, Steven GALLINGER, Yu-Tang GAO, Susan M. GAPSTUR, Montserrat GARCIA-CLOSAS, Reina GARCIA-CLOSAS, Randy D. GASCOYNE, Julie GASTIER-FOSTER, Mia M. GAUDET, J. Michael GAZIANO, Carol GIFFEN, Graham G. GILES, Edward GIOVANNUCCI, Bengt GLIMELIUS, Michael GOGGINS, Nalan GOKGOZ, Alisa M. GOLDSTEIN, Richard GORLICK, Myron GROSS, Robert III GRUBB, Jian GU, Peng GUAN, Marc GUNTER, Huan GUO, Thomas M. HABERMANN, Christopher A. HAIMAN, Dina HALAI, Goran HALLMANS, Manal HASSAN, Claudia HATTINGER, Qincheng HE, Xingzhou HE, Kathy HELZLSOUER, Brian HENDERSON, Roger HENRIKSSON, Henrik HJALGRIM, Judith HOFFMAN-BOLTON, Chancellor HOHENSEE, Theodore R. HOLFORD, Elizabeth A. HOLLY, Yun-Chul HONG, Robert N. HOOVER, Pamela L. HORN-ROSS, G.M. Monawar HOSAIN, H. Dean HOSGOOD, Chin-Fu HSIAO, Nan HU, Wei HU, Zhibin HU, Ming-Shyan HUANG, Jose-Maria HUERTA, Jen-Yu HUNG, Amy HUTCHINSON, Peter D. INSKIP, Rebecca D. JACKSON, Eric J. JACOBS, Mazda JENAB, Hyo-Sung JEON, Bu-Tian JI, Guangfu JIN, Li JIN, Christoffer JOHANSEN, Alison JOHNSON, Yoo Jin JUNG, Rudolph KAAKS, Aruna KAMINENI, Eleanor KANE, Cang Hyan KANG, Margaret R. KARAGAS, Rachel S. KELLY, Kay-Tee KHAW, Christopher KIM, Hee Nam KIM, Jin Hee KIM, Jun Suk KIM, Yeul Hong KIM, Young Tae KIM, Young Chul KIM, Cari M. KITAHARA, Alison P. KLEIN, Robert J. KLEIN, Manolis KOGEVINAS, Takashi KOHNO, Laurence N. KOLONEL, Charles KOOPERBERG, Anne KRICKER, Vittorio KROGH, Hideo KUNITOH, Robert C. KURTZ, Sun-Seog KWEON, Andrea LACROIX, Charles LAWRENCE, Fernando LECANDA, Victor Ho Fun LEE, Donghui LI, Haixin LI, Jihua LI, Yao-Jen LI, Yyqing LI, Linda M. LIAO, Mark LIEBOW, Tracy LIGHTFOOT, Wei-Yen LIM, Chien-Chung LIN, Dongxin LIN, Sasa LINDSTROM, Martha S. LINET, Brian K. LINK, Chenwei LIU, Jianjun LIU, Li LIU, Boerje LJUNGBERG, Josep LLORETA, Simonetta DI LOLLO, Daru LU, Eiluv LUND, Nuria MALATS, Satu MANNISTO, Loic LE MARCHAND, Neyssa MARINA, Giovanna MASALA, Giuseppe MASTRANGELO, Keitaro MATSUO, Marc MAYNADIE, James MCKAY, Roberta MCKEAN-COWDIN, Mads MELBYE, Beatrice S. MELIN, Dominique S. MICHAUD, Tetsuya MITSUDOMI, Alain MONNEREAU, Rebecca MONTALVAN, Lee E. MOORE, Lotte Maxild MORTENSEN, Alexandra NIETERS, Kari E. NORTH, Anne J. NOVAK, Ann L. OBERG, Kenneth OFFIT, In-Jae OH, Sara H. OLSON, Domenico PALLI, William PAO, In Kyu PARK, Jae Yong PARK, Kyong Hwa PARK, Ana PATINO-GARCIA, Sofia PAVANELLO, Petra H.M. PEETERS, Reury-Perng PERNG, Ulrike PETERS, Gloria M. PETERSEN, Piero PICCI, Malcolm C. PIKE, Stefano PORRU, Jennifer PRESCOTT, Ludmila PROKUNINA-OLSSON, Biyun QIAN, You-Lin QIAO, Marco RAIS, Elio RIBOLI, Jacques RIBY, Harvey A. RISCH, Cosmeri RIZZATO, Rebecca RODABOUGH, Eve ROMAN, Morgan ROUPRET, Avima M. RUDER, Silvia de SANJOSE, Ghislaine SCELO, Alan SCHNED, Fredrick SCHUMACHER, Kendra SCHWARTZ, Molly SCHWENN, Katia SCOTLANDI, Adeline SEOW, Consol SERRA, Massimo SERRA, Howard D. SESSO, Veronica Wendy SETIAWAN, Gianluca SEVERI, Richard K. SEVERSON, Tait D. SHANAFELT, Hongbing SHEN, Wei SHEN, Min-Ho SHIN, Kouya SHIRAISHI, Xiao-Ou SHU, Afshan SIDDIQ, Luis SIERRASESUMAGA, Alan Dart Loon SIHOE, Christine F. SKIBOLA, Alex SMITH, Martyn T. SMITH, Melissa C. SOUTHEY, John J. SPINELLI, Anthony STAINES, Meir STAMPFER, Marianna C. STERN, Victoria L. STEVENS, Rachael S. STOLZENBERG-SOLOMON, Jian SU, Wu-Chou SU, Malin SUND, Jae Sook SUNG, Sook Whan SUNG, Wen TAN, Wei TANG, Adonina TARDON, David THOMAS, Carrie A. THOMPSON, Lesley F. TINKER, Roberto TIRABOSCO, Anne TJONNELAND, Ruth C. TRAVIS, Dimitrios TRICHOPOULOS, Fang-Yu TSAI, Ying-Huang TSAI, Margaret TUCKER, Jenny TURNER, Claire M. VAJDIC, Roel C. H. VERMEULEN, Danylo J. VILLANO, Paolo VINEIS, Jarmo VIRTAMO, Kala VISVANATHAN, Jean WACTAWSKI-WENDE, Chaoyu WANG, Chih-Liang WANG, Jiu-Cun WANG, Junwen WANG, Fusheng WEI, Elisabete WEIDERPASS, George J. WEINER, Stephanie WEINSTEIN, Nicolas WENTZENSEN, Emily WHITE, Thomas E. WITZIG, Brian M. WOLPIN, Maria Pik WONG, Chen WU, Guoping WU, Junjie WU, Tangchun WU, Wei WU, Xifeng WU, Yi-Long WU, Jay S. WUNDER, Yong-Bing XIANG, Jun XU, Ping XU, Pan-Chyr YANG, Tsung-Ying YANG, Yuanqing YE, Zhihua YIN, Jun YOKOTA, Ho-ll YOON, Chong-Jen YU, Herbert YU, Kai YU, Jian-Min YUAN, Andrew ZELENETZ, Anne ZELENIUCH-JACQUOTTE, Xu-Chao ZHANG, Yawei ZHANG, Xueying ZHAO, Zhenhong ZHAO, Hong ZHENG, Tongzhang ZHENG, Wei ZHENG, Baosen ZHOU, Meng ZHU, Mariagrazia ZUCCA, Simina M. BOCA, James R. CERHAN, Giovanni M. FERRI, Patricia HARTGE, Chao Agnes HSIUNG, Corrado MAGNANI, Lucia MILIGI, Lindsay M. MORTON, Karin E. SMEDBY, Lauren R. TERAS, Joseph VIJAI, Sophia S. WANG, Paul BRENNAN, Neil E. CAPORASO, David J. HUNTER, Peter KRAFT, Nathaniel ROTHMAN, Debra T. SILVERMAN, Susan L. SLAGER, Stephen J. CHANOCK and Nilanjan CHATTERJEE. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types. \textit{JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE}. CARY: OXFORD UNIV PRESS INC, 2015, vol.~107, No~12, p.~1-11. ISSN~0027-8874. Available from: https://dx.doi.org/10.1093/jnci/djv279.

Basic information
Original name	Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
Authors	SAMPSON, Joshua N. (840 United States of America), William A. WHEELER (840 United States of America), Meredith YEAGER (840 United States of America), Orestis PANAGIOTOU (840 United States of America), Zhaoming WANG (840 United States of America), Sonja I. BERNDT (840 United States of America), Qing LAN (840 United States of America), Christian C. ABNET (840 United States of America), Laufey T. AMUNDADOTTIR (840 United States of America), Jonine D. FIGUEROA (840 United States of America), Maria Teresa LANDI (840 United States of America), Lisa MIRABELLO (840 United States of America), Sharon A. SAVAGE (840 United States of America), Philip R. TAYLOR (840 United States of America), Immaculata DEVIVO (840 United States of America), Katherine A. MCGLYNN (840 United States of America), Mark P. PURDUE (124 Canada), Preetha RAJARAMAN (840 United States of America), Hans-Olov ADAMI (752 Sweden), Anders AHLBOM (752 Sweden), Demetrius ALBANES (840 United States of America), Maria Fernanda AMARY (826 United Kingdom of Great Britain and Northern Ireland), She-Juan AN (156 China), Ulrika ANDERSSON (752 Sweden), Gerald Jr. ANDRIOLE (840 United States of America), Irene L. ANDRULIS (124 Canada), Emanuele ANGELUCCI (380 Italy), Stephen M. ANSELL (840 United States of America), Cecilia ARICI (380 Italy), Bruce K. ARMSTRONG (36 Australia), Alan A. ARSLAN (840 United States of America), Melissa A. AUSTIN (840 United States of America), Dalsu BARIS (840 United States of America), Donald A. BARKAUSKAS (840 United States of America), Bryan A. BASSIG (840 United States of America), Nikolaus BECKER (276 Germany), Yolanda BENAVENTE (724 Spain), Simone BENHAMOU (250 France), Christine BERG (840 United States of America), David VAN DEN BERG (840 United States of America), Leslie BERNSTEIN (840 United States of America), Kimberly A. BERTRAND (840 United States of America), Brenda M. BIRMANN (840 United States of America), Amanda BLACK (840 United States of America), Heiner BOEING (276 Germany), Paolo BOFFETTA (840 United States of America), Marie-Christine BOUTRON-RUAULT (250 France), Paige M. BRACCI (840 United States of America), Louise BRINTON (840 United States of America), Angela R. BROOKS-WILSON (124 Canada), H. Bas BUENO-DE-MESQUITA (528 Netherlands), Laurie BURDETT (840 United States of America), Julie BURING (840 United States of America), Mary Ann BUTLER (840 United States of America), Qiuyin CAI (840 United States of America), Geraldine CANCEL-TASSIN (250 France), Federico CANZIAN (276 Germany), Alfredo CARRATO (724 Spain), Tania CARREON (840 United States of America), Angela CARTA (380 Italy), John K.C. CHAN (156 China), Ellen T. CHANG (840 United States of America), Gee-Chen CHANG (158 Taiwan), I-Shou CHANG (158 Taiwan), Jiang CHANG (156 China), Jenny CHANG-CLAUDE (156 China), Chien-Jen CHEN (158 Taiwan), Chin-Yi CHEN (158 Taiwan), Chu CHEN (840 United States of America), Chung-Hsing CHEN (158 Taiwan), Constance CHEN (840 United States of America), Hongyan CHEN (156 China), Kexin CHEN (156 China), Kuan-Yu CHEN (158 Taiwan), Kun-Chieh CHEN (158 Taiwan), Ying CHEN (702 Singapore), Ying-Hsiang CHEN (158 Taiwan), Yi-Song CHEN (158 Taiwan), Yuh-Min CHEN (158 Taiwan), Li-Hsin CHIEN (158 Taiwan), Maria-Dolores CHIRLAQUE (724 Spain), Jin Eun CHOI (408 Democratic People's Republic of Korea), Yi Young CHOI (408 Democratic People's Republic of Korea), Wong-Ho CHOW (840 United States of America), Charles C. CHUNG (840 United States of America), Jacqueline CLAVEL (250 France), Franoise CLAVEL-CHAPELON (250 France), Pierluigi COCCO (380 Italy), Joanne S. COLT (840 United States of America), Eva COMPERAT (250 France), Lucia CONDE (840 United States of America), Joseph M. CONNORS (124 Canada), David CONTI (840 United States of America), Victoria K. CORTESSIS (840 United States of America), Michelle COTTERCHIO (124 Canada), Wendy COZEN (840 United States of America), Simon CROUCH (826 United Kingdom of Great Britain and Northern Ireland), Marta CROUS-BOU (840 United States of America), Olivier CUSSENOT (250 France), Faith G. DAVIS (124 Canada), Ti DING (756 Switzerland), W. Ryan DIVER (724 Spain), Miren DORRONSORO (724 Spain), Laure DOSSUS (250 France), Eric J. DUELL (724 Spain), Maria Grazia ENNAS (380 Italy), Ralph L. ERICKSON (840 United States of America), Maria FEYCHTING (752 Sweden), Adrienne M. FLANAGAN (826 United Kingdom of Great Britain and Northern Ireland), Lenka FORETOVÁ (203 Czech Republic, guarantor, belonging to the institution), Joseph F. Jr. FRAUMENI (840 United States of America), Neal D. FREEDMAN (840 United States of America), Laura E. Beane FREEMAN (840 United States of America), Charles FUCHS (840 United States of America), Manuela GAGO-DOMINGUEZ (724 Spain), Steven GALLINGER (124 Canada), Yu-Tang GAO (756 Switzerland), Susan M. GAPSTUR (840 United States of America), Montserrat GARCIA-CLOSAS (826 United Kingdom of Great Britain and Northern Ireland), Reina GARCIA-CLOSAS (724 Spain), Randy D. GASCOYNE (124 Canada), Julie GASTIER-FOSTER (840 United States of America), Mia M. GAUDET (840 United States of America), J. Michael GAZIANO (840 United States of America), Carol GIFFEN (840 United States of America), Graham G. GILES (36 Australia), Edward GIOVANNUCCI (840 United States of America), Bengt GLIMELIUS (752 Sweden), Michael GOGGINS (840 United States of America), Nalan GOKGOZ (124 Canada), Alisa M. GOLDSTEIN (840 United States of America), Richard GORLICK (840 United States of America), Myron GROSS (840 United States of America), Robert III GRUBB (840 United States of America), Jian GU (840 United States of America), Peng GUAN (156 China), Marc GUNTER (826 United Kingdom of Great Britain and Northern Ireland), Huan GUO (156 China), Thomas M. HABERMANN (840 United States of America), Christopher A. HAIMAN (826 United Kingdom of Great Britain and Northern Ireland), Dina HALAI (826 United Kingdom of Great Britain and Northern Ireland), Goran HALLMANS (752 Sweden), Manal HASSAN (840 United States of America), Claudia HATTINGER (840 United States of America), Qincheng HE (156 China), Xingzhou HE (156 China), Kathy HELZLSOUER (840 United States of America), Brian HENDERSON (840 United States of America), Roger HENRIKSSON (752 Sweden), Henrik HJALGRIM (208 Denmark), Judith HOFFMAN-BOLTON (840 United States of America), Chancellor HOHENSEE (840 United States of America), Theodore R. HOLFORD (840 United States of America), Elizabeth A. HOLLY (826 United Kingdom of Great Britain and Northern Ireland), Yun-Chul HONG (410 Republic of Korea), Robert N. HOOVER (840 United States of America), Pamela L. HORN-ROSS (840 United States of America), G.M. Monawar HOSAIN (840 United States of America), H. Dean HOSGOOD (840 United States of America), Chin-Fu HSIAO (158 Taiwan), Nan HU (840 United States of America), Wei HU (840 United States of America), Zhibin HU (840 United States of America), Ming-Shyan HUANG (158 Taiwan), Jose-Maria HUERTA (724 Spain), Jen-Yu HUNG (158 Taiwan), Amy HUTCHINSON (840 United States of America), Peter D. INSKIP (840 United States of America), Rebecca D. JACKSON (840 United States of America), Eric J. JACOBS (840 United States of America), Mazda JENAB (250 France), Hyo-Sung JEON (410 Republic of Korea), Bu-Tian JI (840 United States of America), Guangfu JIN (156 China), Li JIN (156 China), Christoffer JOHANSEN (208 Denmark), Alison JOHNSON (840 United States of America), Yoo Jin JUNG (410 Republic of Korea), Rudolph KAAKS (840 United States of America), Aruna KAMINENI (840 United States of America), Eleanor KANE (826 United Kingdom of Great Britain and Northern Ireland), Cang Hyan KANG (158 Taiwan), Margaret R. KARAGAS (840 United States of America), Rachel S. KELLY (826 United Kingdom of Great Britain and Northern Ireland), Kay-Tee KHAW (826 United Kingdom of Great Britain and Northern Ireland), Christopher KIM (410 Republic of Korea), Hee Nam KIM (410 Republic of Korea), Jin Hee KIM (410 Republic of Korea), Jun Suk KIM (410 Republic of Korea), Yeul Hong KIM (410 Republic of Korea), Young Tae KIM (410 Republic of Korea), Young Chul KIM (410 Republic of Korea), Cari M. KITAHARA (840 United States of America), Alison P. KLEIN (840 United States of America), Robert J. KLEIN (840 United States of America), Manolis KOGEVINAS (724 Spain), Takashi KOHNO (392 Japan), Laurence N. KOLONEL (840 United States of America), Charles KOOPERBERG (36 Australia), Anne KRICKER (36 Australia), Vittorio KROGH (380 Italy), Hideo KUNITOH (392 Japan), Robert C. KURTZ (840 United States of America), Sun-Seog KWEON (410 Republic of Korea), Andrea LACROIX (840 United States of America), Charles LAWRENCE (840 United States of America), Fernando LECANDA (724 Spain), Victor Ho Fun LEE (756 Switzerland), Donghui LI (840 United States of America), Haixin LI (756 Switzerland), Jihua LI (158 Taiwan), Yao-Jen LI (158 Taiwan), Yyqing LI (840 United States of America), Linda M. LIAO (840 United States of America), Mark LIEBOW (840 United States of America), Tracy LIGHTFOOT (826 United Kingdom of Great Britain and Northern Ireland), Wei-Yen LIM (702 Singapore), Chien-Chung LIN (158 Taiwan), Dongxin LIN (756 Switzerland), Sasa LINDSTROM (840 United States of America), Martha S. LINET (840 United States of America), Brian K. LINK (840 United States of America), Chenwei LIU (840 United States of America), Jianjun LIU (756 Switzerland), Li LIU (756 Switzerland), Boerje LJUNGBERG (724 Spain), Josep LLORETA (724 Spain), Simonetta DI LOLLO (156 China), Daru LU (156 China), Eiluv LUND (578 Norway), Nuria MALATS (246 Finland), Satu MANNISTO (246 Finland), Loic LE MARCHAND (840 United States of America), Neyssa MARINA (380 Italy), Giovanna MASALA (380 Italy), Giuseppe MASTRANGELO (380 Italy), Keitaro MATSUO (392 Japan), Marc MAYNADIE (250 France), James MCKAY (250 France), Roberta MCKEAN-COWDIN (840 United States of America), Mads MELBYE (840 United States of America), Beatrice S. MELIN (752 Sweden), Dominique S. MICHAUD (752 Sweden), Tetsuya MITSUDOMI (392 Japan), Alain MONNEREAU (250 France), Rebecca MONTALVAN (840 United States of America), Lee E. MOORE (840 United States of America), Lotte Maxild MORTENSEN (840 United States of America), Alexandra NIETERS (276 Germany), Kari E. NORTH (840 United States of America), Anne J. NOVAK (840 United States of America), Ann L. OBERG (840 United States of America), Kenneth OFFIT (840 United States of America), In-Jae OH (178 Congo), Sara H. OLSON (840 United States of America), Domenico PALLI (380 Italy), William PAO (840 United States of America), In Kyu PARK (410 Republic of Korea), Jae Yong PARK (410 Republic of Korea), Kyong Hwa PARK (410 Republic of Korea), Ana PATINO-GARCIA (724 Spain), Sofia PAVANELLO (380 Italy), Petra H.M. PEETERS (826 United Kingdom of Great Britain and Northern Ireland), Reury-Perng PERNG (158 Taiwan), Ulrike PETERS (840 United States of America), Gloria M. PETERSEN (840 United States of America), Piero PICCI (380 Italy), Malcolm C. PIKE (840 United States of America), Stefano PORRU (380 Italy), Jennifer PRESCOTT (840 United States of America), Ludmila PROKUNINA-OLSSON (840 United States of America), Biyun QIAN (158 Taiwan), You-Lin QIAO (156 China), Marco RAIS (380 Italy), Elio RIBOLI (826 United Kingdom of Great Britain and Northern Ireland), Jacques RIBY (840 United States of America), Harvey A. RISCH (840 United States of America), Cosmeri RIZZATO (276 Germany), Rebecca RODABOUGH (250 France), Eve ROMAN (250 France), Morgan ROUPRET (250 France), Avima M. RUDER (840 United States of America), Silvia de SANJOSE (724 Spain), Ghislaine SCELO (250 France), Alan SCHNED (840 United States of America), Fredrick SCHUMACHER (840 United States of America), Kendra SCHWARTZ (380 Italy), Molly SCHWENN (840 United States of America), Katia SCOTLANDI (840 United States of America), Adeline SEOW (702 Singapore), Consol SERRA (724 Spain), Massimo SERRA (380 Italy), Howard D. SESSO (840 United States of America), Veronica Wendy SETIAWAN (840 United States of America), Gianluca SEVERI (36 Australia), Richard K. SEVERSON (840 United States of America), Tait D. SHANAFELT (840 United States of America), Hongbing SHEN (156 China), Wei SHEN (156 China), Min-Ho SHIN (410 Republic of Korea), Kouya SHIRAISHI (840 United States of America), Xiao-Ou SHU (840 United States of America), Afshan SIDDIQ (826 United Kingdom of Great Britain and Northern Ireland), Luis SIERRASESUMAGA (724 Spain), Alan Dart Loon SIHOE (156 China), Christine F. SKIBOLA (840 United States of America), Alex SMITH (826 United Kingdom of Great Britain and Northern Ireland), Martyn T. SMITH (826 United Kingdom of Great Britain and Northern Ireland), Melissa C. SOUTHEY (124 Canada), John J. SPINELLI (124 Canada), Anthony STAINES (372 Ireland), Meir STAMPFER (840 United States of America), Marianna C. STERN (840 United States of America), Victoria L. STEVENS (840 United States of America), Rachael S. STOLZENBERG-SOLOMON (840 United States of America), Jian SU (156 China), Wu-Chou SU (158 Taiwan), Malin SUND (752 Sweden), Jae Sook SUNG (410 Republic of Korea), Sook Whan SUNG (410 Republic of Korea), Wen TAN (156 China), Wei TANG (840 United States of America), Adonina TARDON (724 Spain), David THOMAS (840 United States of America), Carrie A. THOMPSON (840 United States of America), Lesley F. TINKER (826 United Kingdom of Great Britain and Northern Ireland), Roberto TIRABOSCO (826 United Kingdom of Great Britain and Northern Ireland), Anne TJONNELAND (208 Denmark), Ruth C. TRAVIS (826 United Kingdom of Great Britain and Northern Ireland), Dimitrios TRICHOPOULOS (300 Greece), Fang-Yu TSAI (158 Taiwan), Ying-Huang TSAI (158 Taiwan), Margaret TUCKER (840 United States of America), Jenny TURNER (36 Australia), Claire M. VAJDIC (36 Australia), Roel C. H. VERMEULEN (528 Netherlands), Danylo J. VILLANO (840 United States of America), Paolo VINEIS (380 Italy), Jarmo VIRTAMO (840 United States of America), Kala VISVANATHAN (840 United States of America), Jean WACTAWSKI-WENDE (840 United States of America), Chaoyu WANG (840 United States of America), Chih-Liang WANG (158 Taiwan), Jiu-Cun WANG (156 China), Junwen WANG (156 China), Fusheng WEI (156 China), Elisabete WEIDERPASS (752 Sweden), George J. WEINER (840 United States of America), Stephanie WEINSTEIN (840 United States of America), Nicolas WENTZENSEN (840 United States of America), Emily WHITE (840 United States of America), Thomas E. WITZIG (840 United States of America), Brian M. WOLPIN (840 United States of America), Maria Pik WONG (156 China), Chen WU (156 China), Guoping WU (156 China), Junjie WU (156 China), Tangchun WU (156 China), Wei WU (840 United States of America), Xifeng WU (840 United States of America), Yi-Long WU (156 China), Jay S. WUNDER (124 Canada), Yong-Bing XIANG (156 China), Jun XU (156 China), Ping XU (156 China), Pan-Chyr YANG (158 Taiwan), Tsung-Ying YANG (158 Taiwan), Yuanqing YE (840 United States of America), Zhihua YIN (156 China), Jun YOKOTA (724 Spain), Ho-ll YOON (410 Republic of Korea), Chong-Jen YU (158 Taiwan), Herbert YU (840 United States of America), Kai YU (840 United States of America), Jian-Min YUAN (840 United States of America), Andrew ZELENETZ (840 United States of America), Anne ZELENIUCH-JACQUOTTE (840 United States of America), Xu-Chao ZHANG (156 China), Yawei ZHANG (840 United States of America), Xueying ZHAO (156 China), Zhenhong ZHAO (156 China), Hong ZHENG (156 China), Tongzhang ZHENG (840 United States of America), Wei ZHENG (840 United States of America), Baosen ZHOU (156 China), Meng ZHU (840 United States of America), Mariagrazia ZUCCA (840 United States of America), Simina M. BOCA (840 United States of America), James R. CERHAN (840 United States of America), Giovanni M. FERRI (380 Italy), Patricia HARTGE (840 United States of America), Chao Agnes HSIUNG (380 Italy), Corrado MAGNANI (380 Italy), Lucia MILIGI (752 Sweden), Lindsay M. MORTON (752 Sweden), Karin E. SMEDBY (752 Sweden), Lauren R. TERAS (840 United States of America), Joseph VIJAI (840 United States of America), Sophia S. WANG (840 United States of America), Paul BRENNAN (250 France), Neil E. CAPORASO (840 United States of America), David J. HUNTER (840 United States of America), Peter KRAFT (840 United States of America), Nathaniel ROTHMAN (840 United States of America), Debra T. SILVERMAN (840 United States of America), Susan L. SLAGER (840 United States of America), Stephen J. CHANOCK (840 United States of America) and Nilanjan CHATTERJEE (840 United States of America).
Edition	JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, CARY, OXFORD UNIV PRESS INC, 2015, 0027-8874.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30200 3.2 Clinical medicine
Country of publisher	United States of America
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 11.370
RIV identification code	RIV/00216224:14110/15:00087060
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1093/jnci/djv279
UT WoS	000366970900015
Keywords in English	MULTIPLE SUSCEPTIBILITY LOCI; LUNG-CANCER; FAMILIAL RISK; PANCREATIC-CANCER; SWEDEN; INDIVIDUALS; MUTATIONS; RELATIVES; LYMPHOMA; DATABASE
Tags	EL OK
Tags	International impact, Reviewed
Changed by	Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 27/4/2016 16:15.

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 ...

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