Detailed Information on Publication Record
2015
Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands
MICHALICOVÁ, Romana, Přemysl LUBAL, Luis MP LIMA, Rita DELGADO, Petr HERMANN et. al.Basic information
Original name
Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands
Authors
MICHALICOVÁ, Romana (203 Czech Republic, belonging to the institution), Přemysl LUBAL (203 Czech Republic, guarantor, belonging to the institution), Luis MP LIMA (620 Portugal), Rita DELGADO (620 Portugal) and Petr HERMANN (203 Czech Republic, belonging to the institution)
Edition
Wroclaw, Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015), p. 118-119, 2 pp. 2015
Publisher
University of Wroclaw
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10402 Inorganic and nuclear chemistry
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
Publication form
printed version "print"
RIV identification code
RIV/00216224:14310/15:00081670
Organization unit
Faculty of Science
ISSN
Keywords in English
Copper(II) ion; macrocyclic ligands
Tags
Změněno: 28/4/2016 15:53, Ing. Andrea Mikešková
Abstract
V originále
Tetraaza-macrocyclic ligands based on cyclen skeleton are well known for their great ability to bind copper(II) ion leading to formation of metal complexes of high thermodynamic stability and kinetic inertness which are required for their in vivo applications and in medicine. Some complexes of copper radioisotopes are utilized in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h). In addition, the sodium and potassium ions play an important role in biology, e.g. concentration gradient of sodium/potassium ions is important in living organism for many cell functions, and their presence in the solution can affect the kinetic inertness of copper(II) complexes. In this work, the acid-assisted dissociation kinetics of Cu(II) complexes with DOTP-like ligands (e.g. H6do3p, H6do3p1ol, H8dotp) was studied by means of molecular absorption spectroscopy in presence of Li+, Na+ and K+ salts employed as supporting electrolyte. It was found out that these ions significantly influence the rate of dissociation of copper(II) complex in K+ < Na+ < Li+ order and the parameters of chemical model describing this reaction correlate with their ionic size. This effect was not observed for analogous H4dota ligand. This phenomenon is important for interpretation of reaction mechanism of copper(II) complex dissociation and it can be explained by formation of weak complexes between the phosphonate group and the alkali metal ions, analogously as described for lanthanide(III) complexes of DOTP.
Links
| ED1.1.00/02.0068, research and development project |
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| GA13-08336S, research and development project |
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