| JANOVSKÁ, Pavlína, Lucie POPPOVÁ, Karla PLEVOVÁ, Hana PLEŠINGEROVÁ, Martin BĚHAL, Markéta KAUCKÁ, Petra OVESNÁ, Michaela HLOŽKOVÁ, Marek BORSKÝ, Olga STEHLÍKOVÁ, Yvona BRYCHTOVÁ, Michael DOUBEK, Michaela MÁCHALOVÁ, Sivasubramanian BASKAR, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. Clinical cancer research. USA, 2016, vol. 22, No 2, p. 459-469. ISSN 1078-0432. Available from: https://dx.doi.org/10.1158/1078-0432.CCR-15-0154. |
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@article{1341573,
author = {Janovská, Pavlína and Poppová, Lucie and Plevová, Karla and Plešingerová, Hana and Běhal, Martin and Kaucká, Markéta and Ovesná, Petra and Hložková, Michaela and Borský, Marek and Stehlíková, Olga and Brychtová, Yvona and Doubek, Michael and Máchalová, Michaela and Baskar, Sivasubramanian and Kozubík, Alois and Pospíšilová, Šárka and Pavlová, Šárka and Bryja, Vítězslav},
article_location = {USA},
article_number = {2},
doi = {http://dx.doi.org/10.1158/1078-0432.CCR-15-0154},
keywords = {ROR1; Wnt/PCP pathway; CLLB cells},
language = {eng},
issn = {1078-0432},
journal = {Clinical cancer research},
title = {Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia.},
url = {http://clincancerres.aacrjournals.org/content/22/2/459.long},
volume = {22},
year = {2016}
}
TY - JOUR
ID - 1341573
AU - Janovská, Pavlína - Poppová, Lucie - Plevová, Karla - Plešingerová, Hana - Běhal, Martin - Kaucká, Markéta - Ovesná, Petra - Hložková, Michaela - Borský, Marek - Stehlíková, Olga - Brychtová, Yvona - Doubek, Michael - Máchalová, Michaela - Baskar, Sivasubramanian - Kozubík, Alois - Pospíšilová, Šárka - Pavlová, Šárka - Bryja, Vítězslav
PY - 2016
TI - Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia.
JF - Clinical cancer research
VL - 22
IS - 2
SP - 459-469
EP - 459-469
SN - 10780432
KW - ROR1
KW - Wnt/PCP pathway
KW - CLLB cells
UR - http://clincancerres.aacrjournals.org/content/22/2/459.long
N2 - Chronic lymphocytic leukemia (CLL) is the most common leukemia diagnosed in the Western world. Despite increased understanding of the disease biology and better risk stratification, the disease is still considered incurable. In the current study, we provide evidence that CLL cells with positive expression of WNT5A, encoding ligand for the surface receptor ROR1 uniformly upregulated in CLL, define the subgroup of patients with poor prognosis. The most aggressive CLL cases with dysfunctional p53 and mutated SF3B1 are enriched with WNT5A-positive cells, independently of their IGHV mutational status. Functional data show that WNT5A-positive CLL cells have increased motility and deregulated chemotactic responses due to Wnt-5a autocrine signaling. In summary, our data identify WNT5A expression as a new, stable, and strong marker of time to first treatment. Moreover, altered migration properties of WNT5A-positive patient cohort further substantiate the clinical importance of the interaction of CLL cells with their microenvironment.
ER -
JANOVSKÁ, Pavlína, Lucie POPPOVÁ, Karla PLEVOVÁ, Hana PLEŠINGEROVÁ, Martin BĚHAL, Markéta KAUCKÁ, Petra OVESNÁ, Michaela HLOŽKOVÁ, Marek BORSKÝ, Olga STEHLÍKOVÁ, Yvona BRYCHTOVÁ, Michael DOUBEK, Michaela MÁCHALOVÁ, Sivasubramanian BASKAR, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ, Šárka PAVLOVÁ and Vítězslav BRYJA. Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. \textit{Clinical cancer research}. USA, 2016, vol.~22, No~2, p.~459-469. ISSN~1078-0432. Available from: https://dx.doi.org/10.1158/1078-0432.CCR-15-0154.
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