2016
Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet
KOVAĽOVÁ, Ivana, Eva VLČKOVÁ a Josef BEDNAŘÍKZákladní údaje
Originální název
Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet
Autoři
KOVAĽOVÁ, Ivana (703 Slovensko, domácí), Eva VLČKOVÁ (203 Česká republika, garant, domácí) a Josef BEDNAŘÍK (203 Česká republika, domácí)
Vydání
Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2016, 2162-3279
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.157
Kód RIV
RIV/00216224:14110/16:00088851
Organizační jednotka
Lékařská fakulta
UT WoS
000373138200014
Klíčová slova anglicky
cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 6. 3. 2017 11:54, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN.
Návaznosti
ED1.1.00/02.0068, projekt VaV |
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MUNI/A/1358/2014, interní kód MU |
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NT13449, projekt VaV |
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NT13523, projekt VaV |
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