Broadening the spectrum of controls for skin biopsy in painful
neuropathies: spondylotic cervical myelopathy patients with
painful feet

J 2016

Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet

KOVAĽOVÁ, Ivana, Eva VLČKOVÁ and Josef BEDNAŘÍK

Basic information

Original name

Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet

Authors

KOVAĽOVÁ, Ivana (703 Slovakia, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2016, 2162-3279

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.157

RIV identification code

RIV/00216224:14110/16:00088851

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/brb3.444

UT WoS

000373138200014

Keywords in English

cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy

Abstract

V originále

Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MUNI/A/1358/2014, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University, Category A

NT13449, research and development project

Name: Spondylogenní komprese krční míchy - prevalence, diagnostika a prognóza

NT13523, research and development project

Name: Specifické charakteristiky neuropatické bolesti centrálního a periferního typu

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EL_1343118.pdf

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Citovat

KOVAĽOVÁ, Ivana, Eva VLČKOVÁ and Josef BEDNAŘÍK. Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet. Brain and Behavior. Hoboken: John Wiley and Sons Inc., 2016, vol. 6, No 3, p. 1-5. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.444.

@article{1343118,
   author = {Kovaľová, Ivana and Vlčková, Eva and Bednařík, Josef},
   article_location = {Hoboken},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/brb3.444},
   keywords = {cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1343118
AU  - Kovaľová, Ivana - Vlčková, Eva - Bednařík, Josef
PY  - 2016
TI  - Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet
JF  - Brain and Behavior
VL  - 6
IS  - 3
SP  - 1-5
EP  - 1-5
PB  - John Wiley and Sons Inc.
SN  - 21623279
KW  - cervical spondylotic myelopathy
KW  - epidermal nerve fibers
KW  - neuropathic pain
KW  - peripheral neuropathy
KW  - skin biopsy
N2  - Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN.
ER  -

KOVAĽOVÁ, Ivana, Eva VLČKOVÁ and Josef BEDNAŘÍK. Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2016, vol.~6, No~3, p.~1-5. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.444.

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