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@misc{1343615,
author = {Darzentas, Nikos},
address = {Brno},
keywords = {bioinformatics; immunology; hematology; NGS; T-cell; B-cell; ALL},
language = {eng},
location = {Brno},
publisher = {Universitätsklinikum Schleswig-Holstein},
title = {Bioinformatic analysis on T-cell immunoprofiling in relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL)},
year = {2015}
}
TY - GEN
ID - 1343615
AU - Darzentas, Nikos
PY - 2015
TI - Bioinformatic analysis on T-cell immunoprofiling in relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
VL - neuveden
PB - Universitätsklinikum Schleswig-Holstein
CY - Brno
KW - bioinformatics
KW - immunology
KW - hematology
KW - NGS
KW - T-cell
KW - B-cell
KW - ALL
N2 - *Blinatumomab is known to retarget cytotoxic T-cells to cancerous B-cells, in a manner assumed to be polyclonal - however little else is known. To learn more, the molecular analysis of T-cell receptor repertoires before, during and after Blinatumomab treatment is a promising strategy. CEITEC MU and Nikos Darzentas were contracted to perform bioinformatic analysis of ~400 samples of 100 BCP-ALL patients who received Blinatumomab, to eventually check whether it induces long-lasting (oligo)clonal T-cell expansions, and if so, if it is possible to identify any functional patterns between patients. The report is stored in Repository of MU.*
ER -
DARZENTAS, Nikos. \textit{Bioinformatic analysis on T-cell immunoprofiling in relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL)}. Brno: Universitätsklinikum Schleswig-Holstein. 1 s. 2015.
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