DARZENTAS, Nikos. Bioinformatic analysis on T-cell immunoprofiling in relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Brno: Universitätsklinikum Schleswig-Holstein, 2015. 1 pp.
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Basic information
Original name Bioinformatic analysis on T-cell immunoprofiling in relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Authors DARZENTAS, Nikos (300 Greece, guarantor, belonging to the institution).
Edition Brno, 1 pp. 2015.
Publisher Universitätsklinikum Schleswig-Holstein
Other information
Original language English
Type of outcome Research report
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree contents are subject to a state secret
RIV identification code RIV/00216224:14740/15:00087373
Organization unit Central European Institute of Technology
Keywords in English bioinformatics; immunology; hematology; NGS; T-cell; B-cell; ALL
Tags rivok
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 4. 5. 2016 14:11.
Abstract
*Blinatumomab is known to retarget cytotoxic T-cells to cancerous B-cells, in a manner assumed to be polyclonal - however little else is known. To learn more, the molecular analysis of T-cell receptor repertoires before, during and after Blinatumomab treatment is a promising strategy. CEITEC MU and Nikos Darzentas were contracted to perform bioinformatic analysis of ~400 samples of 100 BCP-ALL patients who received Blinatumomab, to eventually check whether it induces long-lasting (oligo)clonal T-cell expansions, and if so, if it is possible to identify any functional patterns between patients. The report is stored in Repository of MU.*
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