Novel electrospun gelatin/oxycellulose nanofibers as a suitable
platform for lung disease modeling

J 2016

Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

ŠVACHOVÁ, Veronika, Lucy VOJTOVÁ, David PAVLIŇÁK, Libor VOJTEK, Veronika SEDLÁKOVÁ et. al.

Basic information

Original name

Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

Authors

ŠVACHOVÁ, Veronika (203 Czech Republic, guarantor), Lucy VOJTOVÁ (203 Czech Republic), David PAVLIŇÁK (203 Czech Republic, belonging to the institution), Libor VOJTEK (203 Czech Republic, belonging to the institution), Veronika SEDLÁKOVÁ (203 Czech Republic, belonging to the institution), Pavel HYRŠL (203 Czech Republic, belonging to the institution), Milan ALBERTI (203 Czech Republic, belonging to the institution), Josef JAROŠ (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution) and Josef JANČÁŘ (203 Czech Republic)

Edition

Materials Science & Engineering C-Materials for Biological Applications, Amsterdam, Elsevier Science, 2016, 0928-4931

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10404 Polymer science

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

odkaz na článek

Impact factor

Impact factor: 4.164

RIV identification code

RIV/00216224:14310/16:00089927

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.msec.2016.05.059

UT WoS

000378952800056

Keywords in English

Oxycellulose;Gelatin;Electrospinning;Nanofibers;Regenerative medicine;Antibacterial

Abstract

V originále

Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.

Links

ED2.1.00/03.0086, research and development project

Name: Regionální VaV centrum pro nízkonákladové plazmové a nanotechnologické povrchové úpravy

EE2.3.20.0185, research and development project

Name: Centrum analýz a modelování tkání a orgánů

LO1411, research and development project

Name: Rozvoj centra pro nízkonákladové plazmové a nanotechnologické povrchové úpravy (Acronym: CEPLANT plus)

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1352/2015, interní kód MU

Name: Zdroje pro tkáňové inženýrství 6 (Acronym: TissueENG 6)

Investor: Masaryk University, Category A

Citovat

ŠVACHOVÁ, Veronika, Lucy VOJTOVÁ, David PAVLIŇÁK, Libor VOJTEK, Veronika SEDLÁKOVÁ, Pavel HYRŠL, Milan ALBERTI, Josef JAROŠ, Aleš HAMPL and Josef JANČÁŘ. Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling. Materials Science & Engineering C-Materials for Biological Applications. Amsterdam: Elsevier Science, 2016, vol. 67, October, p. 493-501. ISSN 0928-4931. Available from: https://dx.doi.org/10.1016/j.msec.2016.05.059.

@article{1345257,
   author = {Švachová, Veronika and Vojtová, Lucy and Pavliňák, David and Vojtek, Libor and Sedláková, Veronika and Hyršl, Pavel and Alberti, Milan and Jaroš, Josef and Hampl, Aleš and Jančář, Josef},
   article_location = {Amsterdam},
   article_number = {October},
   doi = {http://dx.doi.org/10.1016/j.msec.2016.05.059},
   keywords = {Oxycellulose;Gelatin;Electrospinning;Nanofibers;Regenerative medicine;Antibacterial},
   language = {eng},
   issn = {0928-4931},
   journal = {Materials Science & Engineering C-Materials for Biological Applications},
   title = {Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling},
   url = {http://www.sciencedirect.com/science/article/pii/S0928493116304945},
   volume = {67},
   year = {2016}
}

TY  - JOUR
ID  - 1345257
AU  - Švachová, Veronika - Vojtová, Lucy - Pavliňák, David - Vojtek, Libor - Sedláková, Veronika - Hyršl, Pavel - Alberti, Milan - Jaroš, Josef - Hampl, Aleš - Jančář, Josef
PY  - 2016
TI  - Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling
JF  - Materials Science & Engineering C-Materials for Biological Applications
VL  - 67
IS  - October
SP  - 493-501
EP  - 493-501
PB  - Elsevier Science
SN  - 09284931
KW  - Oxycellulose;Gelatin;Electrospinning;Nanofibers;Regenerative medicine;Antibacterial
UR  - http://www.sciencedirect.com/science/article/pii/S0928493116304945
L2  - http://www.sciencedirect.com/science/article/pii/S0928493116304945
N2  - Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.
ER  -

ŠVACHOVÁ, Veronika, Lucy VOJTOVÁ, David PAVLIŇÁK, Libor VOJTEK, Veronika SEDLÁKOVÁ, Pavel HYRŠL, Milan ALBERTI, Josef JAROŠ, Aleš HAMPL and Josef JANČÁŘ. Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling. \textit{Materials Science \&{} Engineering C-Materials for Biological Applications}. Amsterdam: Elsevier Science, 2016, vol.~67, October, p.~493-501. ISSN~0928-4931. Available from: https://dx.doi.org/10.1016/j.msec.2016.05.059.

Detailed Information on Publication Record