ŠVACHOVÁ, Veronika, Lucy VOJTOVÁ, David PAVLIŇÁK, Libor VOJTEK, Veronika SEDLÁKOVÁ, Pavel HYRŠL, Milan ALBERTI, Josef JAROŠ, Aleš HAMPL and Josef JANČÁŘ. Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling. Materials Science & Engineering C-Materials for Biological Applications, Amsterdam: Elsevier Science, 2016, vol. 67, October, p. 493-501. ISSN 0928-4931. doi:10.1016/j.msec.2016.05.059.
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Basic information
Original name Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling
Authors ŠVACHOVÁ, Veronika (203 Czech Republic, guarantor), Lucy VOJTOVÁ (203 Czech Republic), David PAVLIŇÁK (203 Czech Republic, belonging to the institution), Libor VOJTEK (203 Czech Republic, belonging to the institution), Veronika SEDLÁKOVÁ (203 Czech Republic, belonging to the institution), Pavel HYRŠL (203 Czech Republic, belonging to the institution), Milan ALBERTI (203 Czech Republic, belonging to the institution), Josef JAROŠ (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution) and Josef JANČÁŘ (203 Czech Republic).
Edition Materials Science & Engineering C-Materials for Biological Applications, Amsterdam, Elsevier Science, 2016, 0928-4931.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10404 Polymer science
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW odkaz na článek
Impact factor Impact factor: 4.164
RIV identification code RIV/00216224:14310/16:00089927
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.msec.2016.05.059
UT WoS 000378952800056
Keywords in English Oxycellulose;Gelatin;Electrospinning;Nanofibers;Regenerative medicine;Antibacterial
Tags AKR, EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Mgr. David Pavliňák, Ph.D., učo 150650. Changed: 28/5/2017 20:40.
Abstract
Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.
Links
ED2.1.00/03.0086, research and development projectName: Regionální VaV centrum pro nízkonákladové plazmové a nanotechnologické povrchové úpravy
EE2.3.20.0185, research and development projectName: Centrum analýz a modelování tkání a orgánů
LO1411, research and development projectName: Rozvoj centra pro nízkonákladové plazmové a nanotechnologické povrchové úpravy (Acronym: CEPLANT plus)
Investor: Ministry of Education, Youth and Sports of the CR, National Feasibility Programme I
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR, National Feasibility Programme II
MUNI/A/1352/2015, internal MU codeName: Zdroje pro tkáňové inženýrství 6 (Acronym: TissueENG 6)
Investor: Masaryk University, Grant Agency of Masaryk University, Category A
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