New experimental data on the human dermal absorption of
Simazine and Carbendazim help to refine the assessment of human
exposure

J 2016

New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure

BÁNYIOVÁ, Katarína, Anežka SHARMA, Jiří KOHOUTEK, Ivan JUSTAN, Pavel ČUPR et. al.

Basic information

Original name

New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure

Authors

BÁNYIOVÁ, Katarína (703 Slovakia, belonging to the institution), Anežka SHARMA (203 Czech Republic, belonging to the institution), Jiří KOHOUTEK (203 Czech Republic, belonging to the institution), Ivan JUSTAN (203 Czech Republic) and Pavel ČUPR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Chemosphere, OXFORD, Elsevier Science, 2016, 0045-6535

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.208

RIV identification code

RIV/00216224:14310/16:00087938

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.chemosphere.2015.11.018

UT WoS

000369196300020

Keywords in English

Carbendazim; Simazine; Permeability coefficient; Human dermal absorption; Probabilistic risk assessment

Abstract

V originále

Due to their widespread usage, people are exposed to pesticides on a daily basis. Although these compounds may have adverse effects on their health, there is a gap in the data and the methodology needed to reliably quantify the risks of non-occupational human dermal exposure to pesticides. We used Franz cells and human skin in order to measure the dermal absorption kinetics (steady-state flux, lag time and permeability coefficient) of Carbendazim and Simazine. These parameters were then used to refine the dermal exposure model and a probabilistic simulation was used to quantify risks resulting from exposure to pesticide-polluted waters. The experimentally derived permeability coefficient was 0.0034 cm h(-1) for Carbendazim and 0.0047 cm h(-1) for Simazine. Two scenarios (varying exposure duration and concentration, i.e. environmentally relevant and maximum solubility) were used to quantify the human health risks (hazard quotients) for Carbendazim and Simazine. While no risks were determined in the case of either scenario, the permeability coefficient, which is concentration independent and donor, formulation, compound and membrane specific, may be used in other scenarios and exposure models to quantify more precisely the dermally absorbed dose during exposure to polluted water. To the best of our knowledge, the dermal absorption kinetics parameters defined here are being published for the first time. The usage of experimental permeability parameters in combination with probabilistic risk assessment thus provides a new tool for quantifying the risks of human dermal exposure to pesticides.

Links

GA14-27941S, research and development project

Name: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

Investor: Czech Science Foundation

LM2011028, research and development project

Name: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí

Investor: Ministry of Education, Youth and Sports of the CR

LO1214, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BÁNYIOVÁ, Katarína, Anežka SHARMA, Jiří KOHOUTEK, Ivan JUSTAN and Pavel ČUPR. New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure. Chemosphere. OXFORD: Elsevier Science, 2016, vol. 145, February, p. 148-156. ISSN 0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2015.11.018.

@article{1345758,
   author = {Bányiová, Katarína and Sharma, Anežka and Kohoutek, Jiří and Justan, Ivan and Čupr, Pavel},
   article_location = {OXFORD},
   article_number = {February},
   doi = {http://dx.doi.org/10.1016/j.chemosphere.2015.11.018},
   keywords = {Carbendazim; Simazine; Permeability coefficient; Human dermal absorption; Probabilistic risk assessment},
   language = {eng},
   issn = {0045-6535},
   journal = {Chemosphere},
   title = {New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure},
   url = {http://www.sciencedirect.com/science/article/pii/S0045653515303519},
   volume = {145},
   year = {2016}
}

TY  - JOUR
ID  - 1345758
AU  - Bányiová, Katarína - Sharma, Anežka - Kohoutek, Jiří - Justan, Ivan - Čupr, Pavel
PY  - 2016
TI  - New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure
JF  - Chemosphere
VL  - 145
IS  - February
SP  - 148-156
EP  - 148-156
PB  - Elsevier Science
SN  - 00456535
KW  - Carbendazim
KW  - Simazine
KW  - Permeability coefficient
KW  - Human dermal absorption
KW  - Probabilistic risk assessment
UR  - http://www.sciencedirect.com/science/article/pii/S0045653515303519
L2  - http://www.sciencedirect.com/science/article/pii/S0045653515303519
N2  - Due to their widespread usage, people are exposed to pesticides on a daily basis. Although these compounds may have adverse effects on their health, there is a gap in the data and the methodology needed to reliably quantify the risks of non-occupational human dermal exposure to pesticides. We used Franz cells and human skin in order to measure the dermal absorption kinetics (steady-state flux, lag time and permeability coefficient) of Carbendazim and Simazine. These parameters were then used to refine the dermal exposure model and a probabilistic simulation was used to quantify risks resulting from exposure to pesticide-polluted waters. The experimentally derived permeability coefficient was 0.0034 cm h(-1) for Carbendazim and 0.0047 cm h(-1) for Simazine. Two scenarios (varying exposure duration and concentration, i.e. environmentally relevant and maximum solubility) were used to quantify the human health risks (hazard quotients) for Carbendazim and Simazine. While no risks were determined in the case of either scenario, the permeability coefficient, which is concentration independent and donor, formulation, compound and membrane specific, may be used in other scenarios and exposure models to quantify more precisely the dermally absorbed dose during exposure to polluted water. To the best of our knowledge, the dermal absorption kinetics parameters defined here are being published for the first time. The usage of experimental permeability parameters in combination with probabilistic risk assessment thus provides a new tool for quantifying the risks of human dermal exposure to pesticides.
ER  -

BÁNYIOVÁ, Katarína, Anežka SHARMA, Jiří KOHOUTEK, Ivan JUSTAN and Pavel ČUPR. New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure. \textit{Chemosphere}. OXFORD: Elsevier Science, 2016, vol.~145, February, p.~148-156. ISSN~0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2015.11.018.

Detailed Information on Publication Record