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@article{1345758,
author = {Bányiová, Katarína and Sharma, Anežka and Kohoutek, Jiří and Justan, Ivan and Čupr, Pavel},
article_location = {OXFORD},
article_number = {February},
doi = {http://dx.doi.org/10.1016/j.chemosphere.2015.11.018},
keywords = {Carbendazim; Simazine; Permeability coefficient; Human dermal absorption; Probabilistic risk assessment},
language = {eng},
issn = {0045-6535},
journal = {Chemosphere},
title = {New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure},
url = {http://www.sciencedirect.com/science/article/pii/S0045653515303519},
volume = {145},
year = {2016}
}
TY - JOUR
ID - 1345758
AU - Bányiová, Katarína - Sharma, Anežka - Kohoutek, Jiří - Justan, Ivan - Čupr, Pavel
PY - 2016
TI - New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure
JF - Chemosphere
VL - 145
IS - February
SP - 148-156
EP - 148-156
PB - Elsevier Science
SN - 00456535
KW - Carbendazim
KW - Simazine
KW - Permeability coefficient
KW - Human dermal absorption
KW - Probabilistic risk assessment
UR - http://www.sciencedirect.com/science/article/pii/S0045653515303519
L2 - http://www.sciencedirect.com/science/article/pii/S0045653515303519
N2 - Due to their widespread usage, people are exposed to pesticides on a daily basis. Although these compounds may have adverse effects on their health, there is a gap in the data and the methodology needed to reliably quantify the risks of non-occupational human dermal exposure to pesticides. We used Franz cells and human skin in order to measure the dermal absorption kinetics (steady-state flux, lag time and permeability coefficient) of Carbendazim and Simazine. These parameters were then used to refine the dermal exposure model and a probabilistic simulation was used to quantify risks resulting from exposure to pesticide-polluted waters. The experimentally derived permeability coefficient was 0.0034 cm h(-1) for Carbendazim and 0.0047 cm h(-1) for Simazine. Two scenarios (varying exposure duration and concentration, i.e. environmentally relevant and maximum solubility) were used to quantify the human health risks (hazard quotients) for Carbendazim and Simazine. While no risks were determined in the case of either scenario, the permeability coefficient, which is concentration independent and donor, formulation, compound and membrane specific, may be used in other scenarios and exposure models to quantify more precisely the dermally absorbed dose during exposure to polluted water. To the best of our knowledge, the dermal absorption kinetics parameters defined here are being published for the first time. The usage of experimental permeability parameters in combination with probabilistic risk assessment thus provides a new tool for quantifying the risks of human dermal exposure to pesticides.
ER -
BÁNYIOVÁ, Katarína, Anežka SHARMA, Jiří KOHOUTEK, Ivan JUSTAN and Pavel ČUPR. New experimental data on the human dermal absorption of Simazine and Carbendazim help to refine the assessment of human exposure. \textit{Chemosphere}. OXFORD: Elsevier Science, 2016, vol.~145, February, p.~148-156. ISSN~0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2015.11.018.
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