Effect-directed analysis supporting monitoring of aquatic
environments - An in-depth overview

J 2016

Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview

BRACK, Werner, Selim AIT-AISSA, Robert M. BURGESS, Wibke BUSCH, Nicolas CREUSOT et. al.

Basic information

Original name

Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview

Authors

BRACK, Werner (276 Germany), Selim AIT-AISSA (250 France), Robert M. BURGESS (840 United States of America), Wibke BUSCH (276 Germany), Nicolas CREUSOT (250 France), Carolina DI PAOLO (276 Germany), Beate I. ESCHER (276 Germany), L. Mark HEWITT (124 Canada), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution), Juliane HOLLENDER (756 Switzerland), Henner HOLLERT (276 Germany), Willem JONKER (528 Netherlands), Jeroen KOOL (528 Netherlands), Marja LAMOREE (528 Netherlands), Matthias MUSCHKET (276 Germany), Steffen NEUMANN (276 Germany), Pawel ROSTKOWSKI (578 Norway), Christoph RUTTKIES (276 Germany), Jennifer SCHOLLEE (756 Switzerland), Emma L. SCHYMANSKI (756 Switzerland), Tobias SCHULZE (276 Germany), Thomas-Benjamin SEILER (276 Germany), Andrew J. TINDALL (250 France), Gisela De Aragao UMBUZEIRO (76 Brazil), Branislav VRANA (703 Slovakia, guarantor, belonging to the institution) and Martin KRAUSS (276 Germany)

Edition

Science of the Total Environment, AMSTERDAM, Elsevier, 2016, 0048-9697

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.900

RIV identification code

RIV/00216224:14310/16:00089979

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.scitotenv.2015.11.102

UT WoS

000369491500112

Keywords in English

Toxicant identification; Bioassay; Dosing; Enrichment; Fractionation; Non-target analysis

Abstract

V originále

Aquatic environments are often contaminated with complex mixtures of chemicals that may pose a risk to ecosystems and human health. This contamination cannot be addressed with target analysis alone but tools are required to reduce this complexity and identify those chemicals that might cause adverse effects. Effect-directed analysis (EDA) is designed to meet this challenge and faces increasing interest in water and sediment quality monitoring. Thus, the present paper summarizes current experience with the EDA approach and the tools required, and provides practical advice on their application. The paper highlights the need for proper problem formulation and gives general advice for study design. As the EDA approach is directed by toxicity, basic principles for the selection of bioassays are given as well as a comprehensive compilation of appropriate assays, including their strengths and weaknesses. A specific focus is given to strategies for sampling, extraction and bioassay dosing since they strongly impact prioritization of toxicants in EDA. Reduction of sample complexity mainly relies on fractionation procedures, which are discussed in this paper, including quality assurance and quality control. Automated combinations of fractionation, biotesting and chemical analysis using so-called hyphenated tools can enhance the throughput and might reduce the risk of artifacts in laboratory work. The key to determining the chemical structures causing effects is analytical toxicant identification. The latest approaches, tools, software and databases for target-, suspect and non-target screening as well as unknown identification are discussed together with analytical and toxicological confirmation approaches. A better understanding of optimal use and combination of EDA tools will help to design efficient and successful toxicant identification studies in the context of quality monitoring in multiply stressed environments.

Links

603437, interní kód MU

Name: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Acronym: SOLUTIONS)

Investor: European Union, Cooperation

Citovat

BRACK, Werner, Selim AIT-AISSA, Robert M. BURGESS, Wibke BUSCH, Nicolas CREUSOT, Carolina DI PAOLO, Beate I. ESCHER, L. Mark HEWITT, Klára HILSCHEROVÁ, Juliane HOLLENDER, Henner HOLLERT, Willem JONKER, Jeroen KOOL, Marja LAMOREE, Matthias MUSCHKET, Steffen NEUMANN, Pawel ROSTKOWSKI, Christoph RUTTKIES, Jennifer SCHOLLEE, Emma L. SCHYMANSKI, Tobias SCHULZE, Thomas-Benjamin SEILER, Andrew J. TINDALL, Gisela De Aragao UMBUZEIRO, Branislav VRANA and Martin KRAUSS. Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview. Science of the Total Environment. AMSTERDAM: Elsevier, 2016, vol. 544, February, p. 1073-1118. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2015.11.102.

@article{1345760,
   author = {Brack, Werner and AitandAissa, Selim and Burgess, Robert M. and Busch, Wibke and Creusot, Nicolas and Di Paolo, Carolina and Escher, Beate I. and Hewitt, L. Mark and Hilscherová, Klára and Hollender, Juliane and Hollert, Henner and Jonker, Willem and Kool, Jeroen and Lamoree, Marja and Muschket, Matthias and Neumann, Steffen and Rostkowski, Pawel and Ruttkies, Christoph and Schollee, Jennifer and Schymanski, Emma L. and Schulze, Tobias and Seiler, ThomasandBenjamin and Tindall, Andrew J. and Umbuzeiro, Gisela De Aragao and Vrana, Branislav and Krauss, Martin},
   article_location = {AMSTERDAM},
   article_number = {February},
   doi = {http://dx.doi.org/10.1016/j.scitotenv.2015.11.102},
   keywords = {Toxicant identification; Bioassay; Dosing; Enrichment; Fractionation; Non-target analysis},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview},
   url = {http://www.sciencedirect.com/science/article/pii/S0048969715310834},
   volume = {544},
   year = {2016}
}

TY  - JOUR
ID  - 1345760
AU  - Brack, Werner - Ait-Aissa, Selim - Burgess, Robert M. - Busch, Wibke - Creusot, Nicolas - Di Paolo, Carolina - Escher, Beate I. - Hewitt, L. Mark - Hilscherová, Klára - Hollender, Juliane - Hollert, Henner - Jonker, Willem - Kool, Jeroen - Lamoree, Marja - Muschket, Matthias - Neumann, Steffen - Rostkowski, Pawel - Ruttkies, Christoph - Schollee, Jennifer - Schymanski, Emma L. - Schulze, Tobias - Seiler, Thomas-Benjamin - Tindall, Andrew J. - Umbuzeiro, Gisela De Aragao - Vrana, Branislav - Krauss, Martin
PY  - 2016
TI  - Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview
JF  - Science of the Total Environment
VL  - 544
IS  - February
SP  - 1073-1118
EP  - 1073-1118
PB  - Elsevier
SN  - 00489697
KW  - Toxicant identification
KW  - Bioassay
KW  - Dosing
KW  - Enrichment
KW  - Fractionation
KW  - Non-target analysis
UR  - http://www.sciencedirect.com/science/article/pii/S0048969715310834
L2  - http://www.sciencedirect.com/science/article/pii/S0048969715310834
N2  - Aquatic environments are often contaminated with complex mixtures of chemicals that may pose a risk to ecosystems and human health. This contamination cannot be addressed with target analysis alone but tools are required to reduce this complexity and identify those chemicals that might cause adverse effects. Effect-directed analysis (EDA) is designed to meet this challenge and faces increasing interest in water and sediment quality monitoring. Thus, the present paper summarizes current experience with the EDA approach and the tools required, and provides practical advice on their application. The paper highlights the need for proper problem formulation and gives general advice for study design. As the EDA approach is directed by toxicity, basic principles for the selection of bioassays are given as well as a comprehensive compilation of appropriate assays, including their strengths and weaknesses. A specific focus is given to strategies for sampling, extraction and bioassay dosing since they strongly impact prioritization of toxicants in EDA. Reduction of sample complexity mainly relies on fractionation procedures, which are discussed in this paper, including quality assurance and quality control. Automated combinations of fractionation, biotesting and chemical analysis using so-called hyphenated tools can enhance the throughput and might reduce the risk of artifacts in laboratory work. The key to determining the chemical structures causing effects is analytical toxicant identification. The latest approaches, tools, software and databases for target-, suspect and non-target screening as well as unknown identification are discussed together with analytical and toxicological confirmation approaches. A better understanding of optimal use and combination of EDA tools will help to design efficient and successful toxicant identification studies in the context of quality monitoring in multiply stressed environments.
ER  -

BRACK, Werner, Selim AIT-AISSA, Robert M. BURGESS, Wibke BUSCH, Nicolas CREUSOT, Carolina DI PAOLO, Beate I. ESCHER, L. Mark HEWITT, Klára HILSCHEROVÁ, Juliane HOLLENDER, Henner HOLLERT, Willem JONKER, Jeroen KOOL, Marja LAMOREE, Matthias MUSCHKET, Steffen NEUMANN, Pawel ROSTKOWSKI, Christoph RUTTKIES, Jennifer SCHOLLEE, Emma L. SCHYMANSKI, Tobias SCHULZE, Thomas-Benjamin SEILER, Andrew J. TINDALL, Gisela De Aragao UMBUZEIRO, Branislav VRANA and Martin KRAUSS. Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview. \textit{Science of the Total Environment}. AMSTERDAM: Elsevier, 2016, vol.~544, February, p.~1073-1118. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2015.11.102.

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