| MERLO, S., Jan NOVÁK, Nikola TKÁČOVÁ, Nikolajević J. STARČEVIĆ, Šantl M. LETONJA, J. MAKUC, Cokan A. VUJKOVAC, J. LETONJA, D. BREGAR, M. ZORC, M. ROJKO, S. MANKOČ, Peter KRUŽLIAK a D. PETROVIČ. Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus. Balkan Journal of Medical Genetics. Skopje: Macedonian Academy of Sciences and Arts, roč. 18, č. 2, s. 37-42. ISSN 1311-0160. doi:10.1515/bjmg-2015-0084. 2015. |
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@article{1347700,
author = {Merlo, S. and Novák, Jan and Tkáčová, Nikola and Starčević, Nikolajević J. and Letonja, Šantl M. and Makuc, J. and Vujkovac, Cokan A. and Letonja, J. and Bregar, D. and Zorc, M. and Rojko, M. and Mankoč, S. and Kružliak, Peter and Petrovič, D.},
article_location = {Skopje},
article_number = {2},
doi = {http://dx.doi.org/10.1515/bjmg-2015-0084},
keywords = {Angiotensin-converting-enzyme (ACE) gene polymorphism; Association study; Carotid atherosclerosis; Type 2 diabetes mellitus (T2DM)},
language = {eng},
issn = {1311-0160},
journal = {Balkan Journal of Medical Genetics},
title = {Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus},
volume = {18},
year = {2015}
}
TY - JOUR
ID - 1347700
AU - Merlo, S. - Novák, Jan - Tkáčová, Nikola - Starčević, Nikolajević J. - Letonja, Šantl M. - Makuc, J. - Vujkovac, Cokan A. - Letonja, J. - Bregar, D. - Zorc, M. - Rojko, M. - Mankoč, S. - Kružliak, Peter - Petrovič, D.
PY - 2015
TI - Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus
JF - Balkan Journal of Medical Genetics
VL - 18
IS - 2
SP - 37-42
EP - 37-42
PB - Macedonian Academy of Sciences and Arts
SN - 13110160
KW - Angiotensin-converting-enzyme (ACE) gene polymorphism
KW - Association study
KW - Carotid atherosclerosis
KW - Type 2 diabetes mellitus (T2DM)
N2 - The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.
ER -
MERLO, S., Jan NOVÁK, Nikola TKÁČOVÁ, Nikolajevi$\backslash$'c J. STARČEVI$\backslash$'C, Šantl M. LETONJA, J. MAKUC, Cokan A. VUJKOVAC, J. LETONJA, D. BREGAR, M. ZORC, M. ROJKO, S. MANKOČ, Peter KRUŽLIAK a D. PETROVIČ. Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus. \textit{Balkan Journal of Medical Genetics}. Skopje: Macedonian Academy of Sciences and Arts, roč.~18, č.~2, s.~37-42. ISSN~1311-0160. doi:10.1515/bjmg-2015-0084. 2015.
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