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@article{1348791,
author = {Khairnar, Amit Suresh and Rudá, Jana and Dražanová, Eva and Szabó, Nikoletta and Latta, Peter and Arab, Anas and HutterandPaier, Birgit and Havas, Daniel and Windisch, Manfred and Šulcová, Alexandra and Starčuk, Zenon and Király, András and Rektorová, Irena},
article_location = {Hoboken},
article_number = {6},
doi = {http://dx.doi.org/10.1111/jnc.13500},
keywords = {diffusion kurtosis imaging; mean kurtosis; Parkinson’s disease; TBSS; TNWT-61; transgenic mice; a-synuclein},
language = {eng},
issn = {0022-3042},
journal = {Journal of Neurochemistry},
title = {Late-stage alpha-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging},
url = {http://onlinelibrary.wiley.com/doi/10.1111/jnc.13500/epdf},
volume = {136},
year = {2016}
}
TY - JOUR
ID - 1348791
AU - Khairnar, Amit Suresh - Rudá, Jana - Dražanová, Eva - Szabó, Nikoletta - Latta, Peter - Arab, Anas - Hutter-Paier, Birgit - Havas, Daniel - Windisch, Manfred - Šulcová, Alexandra - Starčuk, Zenon - Király, András - Rektorová, Irena
PY - 2016
TI - Late-stage alpha-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging
JF - Journal of Neurochemistry
VL - 136
IS - 6
SP - 1259-1269
EP - 1259-1269
PB - Wiley-Blackwell
SN - 00223042
KW - diffusion kurtosis imaging
KW - mean kurtosis
KW - Parkinson’s disease
KW - TBSS
KW - TNWT-61
KW - transgenic mice
KW - a-synuclein
UR - http://onlinelibrary.wiley.com/doi/10.1111/jnc.13500/epdf
L2 - http://onlinelibrary.wiley.com/doi/10.1111/jnc.13500/epdf
N2 - Diffusion kurtosis imaging (DKI) by measuring non-Gaussian diffusion allows an accurate estimation of the distribution of water molecule displacement and may correctly characterize microstructural brain changes caused by neurodegeneration. The aim of this study was to evaluate the ability of DKI to detect changes induced by -synuclein (-syn) accumulation in -syn over-expressing transgenic mice (TNWT-61) in both gray matter (GM) and white matter (WM) using region of interest (ROI) and tract-based spatial statistics analyses, respectively, and to explore the relationship between -syn accumulation and DKI metrics in our regions of interest. Fourteen-month-old TNWT-61 mice and wild-type (WT) littermates underwent invivo DKI scanning using the Bruker Avance 9.4 Tesla magnetic resonance imaging system. ROI analysis in the GM regions substantia nigra, striatum, hippocampus, sensorimotor cortex, and thalamus and tract-based spatial statistics analysis in WM were performed. Immunohistochemistry for -syn was performed in TNWT-61 mice and correlated with DKI findings. We found increased kurtosis and decreased diffusivity values in GM regions such as the thalamus and sensorimotor cortex, and in WM regions such as the external and internal capsule, mamillothalamic tract, anterior commissure, cingulum, and corpus callosum in TNWT-61 mice as compared to WT mice. Furthermore, we report for the first time that -syn accumulation is positively correlated with kurtosis and negatively correlated with diffusivity in the thalamus. The study provides evidence of an association between the amount of -syn and the magnitude of DKI metric changes in the ROIs, with the potential of improving the clinical diagnosis of Parkinson's disease.
ER -
KHAIRNAR, Amit Suresh, Jana RUDÁ, Eva DRAŽANOVÁ, Nikoletta SZABÓ, Peter LATTA, Anas ARAB, Birgit HUTTER-PAIER, Daniel HAVAS, Manfred WINDISCH, Alexandra ŠULCOVÁ, Zenon STARČUK, András KIRÁLY and Irena REKTOROVÁ. Late-stage alpha-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging. \textit{Journal of Neurochemistry}. Hoboken: Wiley-Blackwell, 2016, vol.~136, No~6, p.~1259-1269. ISSN~0022-3042. Available from: https://dx.doi.org/10.1111/jnc.13500.
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