The role of the endoplasmic reticulum stress in stemness, pluripotency and development

KRATOCHVÍLOVÁ, Kateřina, Lukáš MORÁŇ, Stanislava PAĎOUROVÁ, Stanislav STEJSKAL, Lenka TESAŘOVÁ, Pavel ŠIMARA, Aleš HAMPL, Irena KRONTORÁD KOUTNÁ and Petr VAŇHARA. The role of the endoplasmic reticulum stress in stemness, pluripotency and development. European Journal of Cell Biology. Jena: Elsevier GMBH, 2016, vol. 95, 3-5, p. 115-123. ISSN 0171-9335. Available from: https://dx.doi.org/10.1016/j.ejcb.2016.02.002.

Basic information

Original name

The role of the endoplasmic reticulum stress in stemness, pluripotency and development

Authors

KRATOCHVÍLOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Lukáš MORÁŇ (203 Czech Republic, belonging to the institution), Stanislava PAĎOUROVÁ (703 Slovakia, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution), Lenka TESAŘOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠIMARA (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution), Irena KRONTORÁD KOUTNÁ (203 Czech Republic, belonging to the institution) and Petr VAŇHARA (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Journal of Cell Biology, Jena, Elsevier GMBH, 2016, 0171-9335

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.712

RIV identification code

RIV/00216224:14110/16:00088011

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ejcb.2016.02.002

UT WoS

000374916100001

Keywords in English

Endoplasmic reticulum stress; Unfolded protein response; Embryonic stem cells; Pluripotency; Development

Tags

cbia-web, EL OK, podil

Tags

International impact, Reviewed

---

Abstract

V originále

The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.

---

Links

GA15-11707S, research and development project	Name: Centrosomální abnormality u lidských pluripotentních kmenových buněk. Investor: Czech Science Foundation
GBP302/12/G157, research and development project	Name: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii Investor: Czech Science Foundation
LM2015090, research and development project	Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN) Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1352/2015, interní kód MU	Name: Zdroje pro tkáňové inženýrství 6 (Acronym: TissueENG 6) Investor: Masaryk University, Category A
MUNI/M/1050/2013, interní kód MU	Name: Automatizovaná analýza elektronmikroskopických snímků pro použití v biologii a medicíně (Acronym: Analýza TEM snímků) Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects