The role of the endoplasmic reticulum stress in stemness, pluripotency and development

KRATOCHVÍLOVÁ, Kateřina, Lukáš MORÁŇ, Stanislava PAĎOUROVÁ, Stanislav STEJSKAL, Lenka TESAŘOVÁ, Pavel ŠIMARA, Aleš HAMPL, Irena KRONTORÁD KOUTNÁ and Petr VAŇHARA. The role of the endoplasmic reticulum stress in stemness, pluripotency and development. European Journal of Cell Biology. Jena: Elsevier GMBH, 2016, vol. 95, 3-5, p. 115-123. ISSN 0171-9335. Available from: https://dx.doi.org/10.1016/j.ejcb.2016.02.002.

Basic information

• Original name: The role of the endoplasmic reticulum stress in stemness, pluripotency and development
• Authors: KRATOCHVÍLOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Lukáš MORÁŇ (203 Czech Republic, belonging to the institution), Stanislava PAĎOUROVÁ (703 Slovakia, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution), Lenka TESAŘOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠIMARA (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution), Irena KRONTORÁD KOUTNÁ (203 Czech Republic, belonging to the institution) and Petr VAŇHARA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: European Journal of Cell Biology, Jena, Elsevier GMBH, 2016, 0171-9335.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.712
• RIV identification code: RIV/00216224:14110/16:00088011
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.ejcb.2016.02.002
• UT WoS: 000374916100001
• Keywords in English: Endoplasmic reticulum stress; Unfolded protein response; Embryonic stem cells; Pluripotency; Development
• Tags: cbia-web, EL OK, podil
• Tags: International impact, Reviewed

Abstract

The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.

Links

• GA15-11707S, research and development project: Name: Centrosomální abnormality u lidských pluripotentních kmenových buněk.

Investor: Czech Science Foundation

• GBP302/12/G157, research and development project: Name: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii

Investor: Czech Science Foundation

• LM2015090, research and development project: Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1352/2015, interní kód MU: Name: Zdroje pro tkáňové inženýrství 6 (Acronym: TissueENG 6)

Investor: Masaryk University, Category A

• MUNI/M/1050/2013, interní kód MU: Name: Automatizovaná analýza elektronmikroskopických snímků pro použití v biologii a medicíně (Acronym: Analýza TEM snímků)

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects