| PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study. Medical & Biological Engineering & Computing. Heidelberg: Springer Heidelberg, 2016, vol. 54, No 5, p. 753-762. ISSN 0140-0118. Available from: https://dx.doi.org/10.1007/s11517-015-1366-8. |
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@article{1348900,
author = {Pásek, Michal and Bébarová, Markéta and Christé, Georges and Šimurdová, Milena and Šimurda, Jiří},
article_location = {Heidelberg},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s11517-015-1366-8},
keywords = {Ethanol; Cardiomyocyte; Action potential; Rat ventricular cell model; Human ventricular cell model},
language = {eng},
issn = {0140-0118},
journal = {Medical & Biological Engineering & Computing},
title = {Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study},
volume = {54},
year = {2016}
}
TY - JOUR
ID - 1348900
AU - Pásek, Michal - Bébarová, Markéta - Christé, Georges - Šimurdová, Milena - Šimurda, Jiří
PY - 2016
TI - Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study
JF - Medical & Biological Engineering & Computing
VL - 54
IS - 5
SP - 753-762
EP - 753-762
PB - Springer Heidelberg
SN - 01400118
KW - Ethanol
KW - Cardiomyocyte
KW - Action potential
KW - Rat ventricular cell model
KW - Human ventricular cell model
N2 - Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca2+ dynamics seem to be altered as well. In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocytes to assess the share of ionic current components in ethanol-induced changes in AP configuration and cytosolic Ca2+ transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes in AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at a parts per thousand yen8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of I (K1). The cytosolic Ca2+ transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of I (Ca). In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on I (Kr), the key repolarising current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals.
ER -
PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study. \textit{Medical \&{} Biological Engineering \&{} Computing}. Heidelberg: Springer Heidelberg, 2016, vol.~54, No~5, p.~753-762. ISSN~0140-0118. Available from: https://dx.doi.org/10.1007/s11517-015-1366-8.
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