Other formats:
BibTeX
LaTeX
RIS
@article{1349540,
author = {Hill, N. and Paruch, Kamil and Švenda, Jakub},
article_location = {OXFORD},
article_number = {24},
doi = {http://dx.doi.org/10.1016/j.tet.2016.04.004},
keywords = {Convergent synthesis; Annulation; Convergency; Natural products; Organic synthesis},
language = {eng},
issn = {0040-4020},
journal = {Tetrahedron},
title = {Late-stage annulative convergency in natural product synthesis},
url = {http://www.sciencedirect.com/science/article/pii/S0040402016302575},
volume = {72},
year = {2016}
}
TY - JOUR
ID - 1349540
AU - Hill, N. - Paruch, Kamil - Švenda, Jakub
PY - 2016
TI - Late-stage annulative convergency in natural product synthesis
JF - Tetrahedron
VL - 72
IS - 24
SP - 3345-3368
EP - 3345-3368
PB - Pergamon Press
SN - 00404020
KW - Convergent synthesis
KW - Annulation
KW - Convergency
KW - Natural products
KW - Organic synthesis
UR - http://www.sciencedirect.com/science/article/pii/S0040402016302575
L2 - http://www.sciencedirect.com/science/article/pii/S0040402016302575
N2 - In this Review, we present illustrative examples of recent synthesesof complex natural products completed through the latestage convergent coupling of fragments of similar size in either i) an annulation reaction or ii) a short, small ring-forming reaction sequence. The term we use to describe these criteria is late-stage annulative convergency. We focus on such bond-pair retrosynthetic disconnections because they can be more challenging to recognize and often result in a greater degree of structural simplification. While not covered here, the general benefits of a convergent strategy apply equally to single-bond couplings or larger ring constructions (e.g., linear and macrocyclic molecules). The Review covers the literature from 2000 through the end of 2015 and is intended to present highlights of late-stage annulative convergency rather than an exhaustive coverage of total syntheses with convergent features.
ER -
HILL, N., Kamil PARUCH and Jakub ŠVENDA. Late-stage annulative convergency in natural product synthesis. \textit{Tetrahedron}. OXFORD: Pergamon Press, vol.~72, No~24, p.~3345-3368. ISSN~0040-4020. doi:10.1016/j.tet.2016.04.004. 2016.
|
