MISHRA, Nibha, Sandeep SAXENA, Surabhi RUIA, Senthamizh PRASAD, Vinita SINGH, Vinay KHANNA, Robert STAFFA, Ludovit GASPAR a Peter KRUZLIAK. Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study. Journal of Diabetes and its Complications. New York: Elsevier Science INC, roč. 30, č. 5, s. 868-872. ISSN 1056-8727. doi:10.1016/j.jdiacomp.2016.03.011. 2016. |
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@article{1349545, author = {Mishra, Nibha and Saxena, Sandeep and Ruia, Surabhi and Prasad, Senthamizh and Singh, Vinita and Khanna, Vinay and Staffa, Robert and Gaspar, Ludovit and Kruzliak, Peter}, article_location = {New York}, article_number = {5}, doi = {http://dx.doi.org/10.1016/j.jdiacomp.2016.03.011}, keywords = {Advanced glycation end product; Diabetic retinopathy; N-epsilon-Carboxy methyl lysine; Retinal pigment epithelium; Spectral domain optical coherence tomography}, language = {eng}, issn = {1056-8727}, journal = {Journal of Diabetes and its Complications}, title = {Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study}, volume = {30}, year = {2016} }
TY - JOUR ID - 1349545 AU - Mishra, Nibha - Saxena, Sandeep - Ruia, Surabhi - Prasad, Senthamizh - Singh, Vinita - Khanna, Vinay - Staffa, Robert - Gaspar, Ludovit - Kruzliak, Peter PY - 2016 TI - Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study JF - Journal of Diabetes and its Complications VL - 30 IS - 5 SP - 868-872 EP - 868-872 PB - Elsevier Science INC SN - 10568727 KW - Advanced glycation end product KW - Diabetic retinopathy KW - N-epsilon-Carboxy methyl lysine KW - Retinal pigment epithelium KW - Spectral domain optical coherence tomography N2 - Purpose: To evaluate the association of serum levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML), an advanced glycation end product with topographic alterations in retinal pigment epithelium (RPE) in diabetic retinopathy on spectral domain optical coherence tomography (SD-OCT). Method: Consecutive cases of type 2 diabetes mellitus with no retinopathy (n = 20); non-proliferative diabetic retinopathy (n = 20); proliferative diabetic retinopathy (n = 20) and healthy controls (n = 20) between the ages of 40 and 65 years were included. RPE alterations were graded on segmentation map of SD-OCT: grade 0, No RPE alterations; grade 1, RPE alterations in up to two quadrants and grade 2, RPE alterations in more than two quadrants. Serum level of N-epsilon-CML and glycated hemoglobin (HbA1c) was analyzed using the standard protocol. Statistical analysis was done. Results: Significant increase in N-epsilon-CML was observed with increased severity of diabetic retinopathy (F = 34.1; p < 0.0001). Fisher exact test revealed significant increase in grades of RPE alterations with increased severity of diabetic retinopathy (p < 0.001). Univariate ordinal regression analysis was done to calculate the risk of progression in grades of RPE alteration with individual changes in variables like duration of diabetes (odds ratio = 1.37; p = 0.001), HbA1c (odds ratio = 1.37; p = 0.002) and N-epsilon-CML (odds ratio = 1.37; p < 0.0001). Multivariate ordinal regression analysis for predicting progression in grades of RPE alteration revealed N epsilon-CML to be an independent predictor of increase in grades of RPE alteration (adjusted odds ratio = 1.07; p < 0.01) when duration of diabetes and HbA1c were held constant. Conclusion: Increase in serum levels of N-epsilon-Carboxy methyl lysine is significantly associated with topographic alterations in RPE. Grades of RPE alteration increase significantly with increased severity of diabetic retinopathy. ER -
MISHRA, Nibha, Sandeep SAXENA, Surabhi RUIA, Senthamizh PRASAD, Vinita SINGH, Vinay KHANNA, Robert STAFFA, Ludovit GASPAR a Peter KRUZLIAK. Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study. \textit{Journal of Diabetes and its Complications}. New York: Elsevier Science INC, roč.~30, č.~5, s.~868-872. ISSN~1056-8727. doi:10.1016/j.jdiacomp.2016.03.011. 2016.
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