MISHRA, Nibha, Sandeep SAXENA, Surabhi RUIA, Senthamizh PRASAD, Vinita SINGH, Vinay KHANNA, Robert STAFFA, Ludovit GASPAR a Peter KRUZLIAK. Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study. Journal of Diabetes and its Complications. New York: Elsevier Science INC, roč. 30, č. 5, s. 868-872. ISSN 1056-8727. doi:10.1016/j.jdiacomp.2016.03.011. 2016.
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Základní údaje
Originální název Increased levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study
Autoři MISHRA, Nibha (356 Indie), Sandeep SAXENA (356 Indie), Surabhi RUIA (356 Indie), Senthamizh PRASAD (356 Indie), Vinita SINGH (356 Indie), Vinay KHANNA (356 Indie), Robert STAFFA (203 Česká republika, garant, domácí), Ludovit GASPAR (703 Slovensko) a Peter KRUZLIAK (203 Česká republika).
Vydání Journal of Diabetes and its Complications, New York, Elsevier Science INC, 2016, 1056-8727.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30202 Endocrinology and metabolism
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 2.734
Kód RIV RIV/00216224:14110/16:00090351
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.jdiacomp.2016.03.011
UT WoS 000378759700020
Klíčová slova anglicky Advanced glycation end product; Diabetic retinopathy; N-epsilon-Carboxy methyl lysine; Retinal pigment epithelium; Spectral domain optical coherence tomography
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 25. 8. 2016 11:31.
Anotace
Purpose: To evaluate the association of serum levels of N-epsilon-Carboxy methyl lysine (N-epsilon-CML), an advanced glycation end product with topographic alterations in retinal pigment epithelium (RPE) in diabetic retinopathy on spectral domain optical coherence tomography (SD-OCT). Method: Consecutive cases of type 2 diabetes mellitus with no retinopathy (n = 20); non-proliferative diabetic retinopathy (n = 20); proliferative diabetic retinopathy (n = 20) and healthy controls (n = 20) between the ages of 40 and 65 years were included. RPE alterations were graded on segmentation map of SD-OCT: grade 0, No RPE alterations; grade 1, RPE alterations in up to two quadrants and grade 2, RPE alterations in more than two quadrants. Serum level of N-epsilon-CML and glycated hemoglobin (HbA1c) was analyzed using the standard protocol. Statistical analysis was done. Results: Significant increase in N-epsilon-CML was observed with increased severity of diabetic retinopathy (F = 34.1; p < 0.0001). Fisher exact test revealed significant increase in grades of RPE alterations with increased severity of diabetic retinopathy (p < 0.001). Univariate ordinal regression analysis was done to calculate the risk of progression in grades of RPE alteration with individual changes in variables like duration of diabetes (odds ratio = 1.37; p = 0.001), HbA1c (odds ratio = 1.37; p = 0.002) and N-epsilon-CML (odds ratio = 1.37; p < 0.0001). Multivariate ordinal regression analysis for predicting progression in grades of RPE alteration revealed N epsilon-CML to be an independent predictor of increase in grades of RPE alteration (adjusted odds ratio = 1.07; p < 0.01) when duration of diabetes and HbA1c were held constant. Conclusion: Increase in serum levels of N-epsilon-Carboxy methyl lysine is significantly associated with topographic alterations in RPE. Grades of RPE alteration increase significantly with increased severity of diabetic retinopathy.
VytisknoutZobrazeno: 28. 3. 2024 18:28