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@article{1349624,
author = {Lenárt, Peter and Bienertová Vašků, Julie},
article_location = {Clare},
article_number = {July},
doi = {http://dx.doi.org/10.1016/j.mad.2016.06.002},
keywords = {Aging; Entropy; Double strand breaks; Chromatin; DNA damage},
language = {eng},
issn = {0047-6374},
journal = {Mechanisms of Ageing and Development},
title = {Double strand breaks may be a missing link between entropy and aging},
url = {https://www.sciencedirect.com/science/article/pii/S0047637416300860?via%3Dihub},
volume = {157},
year = {2016}
}
TY - JOUR
ID - 1349624
AU - Lenárt, Peter - Bienertová Vašků, Julie
PY - 2016
TI - Double strand breaks may be a missing link between entropy and aging
JF - Mechanisms of Ageing and Development
VL - 157
IS - July
SP - 1-6
EP - 1-6
PB - Elsevier Ireland Ltd.
SN - 00476374
KW - Aging
KW - Entropy
KW - Double strand breaks
KW - Chromatin
KW - DNA damage
UR - https://www.sciencedirect.com/science/article/pii/S0047637416300860?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0047637416300860?via%3Dihub
N2 - It has been previously suggested that an increase in entropy production leads to aging. However, the mechanisms linking increased entropy production in living mass to aging are currently unclear. Even though entropy cannot be easily associated with any specific molecular damage, the increase of entropy in structural mass may be connected with heat stress, which is known to generate double strand breaks. Double strand breaks, which are in turn known to play an important role in process of aging, are thus connected to both aging and an increase of entropy. In view of these associations, we propose a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype. This not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.
ER -
LENÁRT, Peter a Julie BIENERTOVÁ VAŠKŮ. Double strand breaks may be a missing link between entropy and aging. \textit{Mechanisms of Ageing and Development}. Clare: Elsevier Ireland Ltd., 2016, roč.~157, July, s.~1-6. ISSN~0047-6374. Dostupné z: https://dx.doi.org/10.1016/j.mad.2016.06.002.
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