Altered Neural Correlate of the Self-Agency Experience in
First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

J 2016

Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

SPANIEL, Filip; Jaroslav TINTERA; Jan RYDLO; Ibrahim IBRAHIM; Tomáš KAŠPÁREK et. al.

Základní údaje

Originální název

Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

Autoři

SPANIEL, Filip (203 Česká republika); Jaroslav TINTERA (203 Česká republika); Jan RYDLO (203 Česká republika); Ibrahim IBRAHIM (203 Česká republika); Tomáš KAŠPÁREK (203 Česká republika, garant, domácí); Jiri HORACEK (203 Česká republika); Natalie ZAYTSEVA (203 Česká republika); Martin MATEJKA (203 Česká republika); Marketa FIALOVA (203 Česká republika); Andrea SLOVAKOVA (203 Česká republika); Pavol MIKOLAS (203 Česká republika); Tomas MELICHER (203 Česká republika); Natalie GÖRNEROVA (203 Česká republika); Cyril HÖSCHL (203 Česká republika) a Tomas HAJEK (203 Česká republika)

Vydání

Schizophrenia Bulletin, Oxford, Oxford University Press, 2016, 0586-7614

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 7.575

Kód RIV

RIV/00216224:14110/16:00090378

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1093/schbul/sbv188

UT WoS

000385280800013

EID Scopus

2-s2.0-84979224991

Klíčová slova anglicky

first-episode schizophrenia; neuroimaging; fMRI; self-agency; independent component analysis

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 1. 2017 09:42, Soňa Böhmová

Anotace

V originále

Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Citovat

SPANIEL, Filip; Jaroslav TINTERA; Jan RYDLO; Ibrahim IBRAHIM; Tomáš KAŠPÁREK; Jiri HORACEK; Natalie ZAYTSEVA; Martin MATEJKA; Marketa FIALOVA; Andrea SLOVAKOVA; Pavol MIKOLAS; Tomas MELICHER; Natalie GÖRNEROVA; Cyril HÖSCHL a Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, roč. 42, č. 4, s. 916-925. ISSN 0586-7614. Dostupné z: https://doi.org/10.1093/schbul/sbv188.

@article{1349625,
   author = {Spaniel, Filip and Tintera, Jaroslav and Rydlo, Jan and Ibrahim, Ibrahim and Kašpárek, Tomáš and Horacek, Jiri and Zaytseva, Natalie and Matejka, Martin and Fialova, Marketa and Slovakova, Andrea and Mikolas, Pavol and Melicher, Tomas and Görnerova, Natalie and Höschl, Cyril and Hajek, Tomas},
   article_location = {Oxford},
   article_number = {4},
   doi = {https://doi.org/10.1093/schbul/sbv188},
   keywords = {first-episode schizophrenia; neuroimaging; fMRI; self-agency; independent component analysis},
   language = {eng},
   issn = {0586-7614},
   journal = {Schizophrenia Bulletin},
   title = {Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study},
   volume = {42},
   year = {2016}
}

TY  - JOUR
ID  - 1349625
AU  - Spaniel, Filip - Tintera, Jaroslav - Rydlo, Jan - Ibrahim, Ibrahim - Kašpárek, Tomáš - Horacek, Jiri - Zaytseva, Natalie - Matejka, Martin - Fialova, Marketa - Slovakova, Andrea - Mikolas, Pavol - Melicher, Tomas - Görnerova, Natalie - Höschl, Cyril - Hajek, Tomas
PY  - 2016
TI  - Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study
JF  - Schizophrenia Bulletin
VL  - 42
IS  - 4
SP  - 916-925
EP  - 916-925
PB  - Oxford University Press
SN  - 05867614
KW  - first-episode schizophrenia
KW  - neuroimaging
KW  - fMRI
KW  - self-agency
KW  - independent component analysis
N2  - Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
ER  -

SPANIEL, Filip; Jaroslav TINTERA; Jan RYDLO; Ibrahim IBRAHIM; Tomáš KAŠPÁREK; Jiri HORACEK; Natalie ZAYTSEVA; Martin MATEJKA; Marketa FIALOVA; Andrea SLOVAKOVA; Pavol MIKOLAS; Tomas MELICHER; Natalie GÖRNEROVA; Cyril HÖSCHL a Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, roč.~42, č.~4, s.~916-925. ISSN~0586-7614. Dostupné z: https://doi.org/10.1093/schbul/sbv188.

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