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@proceedings{1350529, author = {Kratochvílová, Kateřina and Moráň, Lukáš and Font Calvarons, Cristina and Baltasová, Ivana and Hampl, Aleš and Vaňhara, Petr}, booktitle = {12th International Congress of Cell Biology, Programme & Abstract Book}, keywords = {endoplasmic reticulum stress, ER stress, UPR, senescence, ovarian surface epithelium, epithelial-to-mesenchymal transition, EMT}, title = {ER Stress Modulates Senescence and EMT in Ovarian Surface Epithelium}, url = {http://iccb2016.org/detailed-poster-list.htm}, year = {2016} }
TY - CONF ID - 1350529 AU - Kratochvílová, Kateřina - Moráň, Lukáš - Font Calvarons, Cristina - Baltasová, Ivana - Hampl, Aleš - Vaňhara, Petr PY - 2016 TI - ER Stress Modulates Senescence and EMT in Ovarian Surface Epithelium KW - endoplasmic reticulum stress, ER stress, UPR, senescence, ovarian surface epithelium, epithelial-to-mesenchymal transition, EMT UR - http://iccb2016.org/detailed-poster-list.htm N2 - Endoplasmic reticulum (ER) is a multifunctional organelle primarily responsible for protein synthesis and folding. Disruption of ER function triggers a protective machinery called the unfolded protein response (UPR). UPR pathways then arrest the RNA translation and increase the production of ER chaperones to alleviate ER stress, or, if the stress cannot be resolved, UPR induces phenotypic change and/or apoptosis. Cellular senescence is a complex cell phenotype, whereby cells irreversibly cease to divide after a number of passages. It can be induced by telomere shortening, DNA damage, oxidative stress and activation of some oncogenes. Senescent cells accumulate with age in tissues and are assumed to play a role in age-associated diseases, such as Alzheimer disease or cancer. In our work, induction of senescence lead to upregulation of UPR hallmark proteins and interestingly, alleviation of ER stress by inhibition of UPR signaling or by chemical chaperons, overridden the onset of senescence. In summary, these results indicate a biologically relevant link between UPR and senescence of OSE cells that may contribute to better understanding of ovarian pathologies extending the portfolio of druggable molecular targets. ER -
KRATOCHVÍLOVÁ, Kateřina, Lukáš MORÁŇ, Cristina FONT CALVARONS, Ivana BALTASOVÁ, Aleš HAMPL a Petr VAŇHARA. ER Stress Modulates Senescence and EMT in Ovarian Surface Epithelium. In \textit{12th International Congress of Cell Biology, Programme \&{} Abstract Book}. 2016.
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