HORSKÁ, Kateřina, Jana RUDÁ, Zuzana BABINSKÁ, Michal KARPISEK, Regina DEMLOVÁ, Radka OPATRILOVA, Pavel SUCHY and Hana KOTOLOVA. Olanzapine-depot administration induces time-dependent changes inadipose tissue endocrine function in rats. Psychoneuroendocrinology, Oxford: Pergamon-Elsevier Science LTD, 2016, vol. 73, "neuvedeno", p. 177-185. ISSN 0306-4530. doi:10.1016/j.psyneuen.2016.07.218.
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Basic information
Original name Olanzapine-depot administration induces time-dependent changes inadipose tissue endocrine function in rats
Name in Czech Podání depotního olanzapinu způsobuje na čase závislé změny v endokrinních funkcích tukové tkáně u potkana
Authors HORSKÁ, Kateřina (203 Czech Republic), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution), Zuzana BABINSKÁ (703 Slovakia, belonging to the institution), Michal KARPISEK (203 Czech Republic), Regina DEMLOVÁ (203 Czech Republic, belonging to the institution), Radka OPATRILOVA (203 Czech Republic), Pavel SUCHY (203 Czech Republic) and Hana KOTOLOVA (203 Czech Republic).
Edition Psychoneuroendocrinology, Oxford, Pergamon-Elsevier Science LTD, 2016, 0306-4530.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.788
RIV identification code RIV/00216224:14110/16:00090460
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.psyneuen.2016.07.218
UT WoS 000385324800021
Keywords in English Adipokine; Adipose tissue; Dyslipidemia; Leptin; Olanzapine; Sprague-Dawley rats
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 13/7/2020 10:01.
Objective Metabolic adverse effects of atypical antipsychotics (AAP) contribute significantly to increased risk of cardiovascular morbidity and mortality in patients suffering from schizophrenia. Extensive preclinical research has addressed this issue over the past years, though mechanisms underlying these adverse effects of AAP are still not understood completely. Recently, attention is drawn towards the role of adipose tissue metabolism and neurohormonal regulations. Methods The aim of this study was to evaluate the time-dependent effects of olanzapine depot administration at clinically relevant dosing on the regulation of energy homeostasis, glucose and lipid metabolism, gastrointestinal and adipose tissue-derived hormones involved in energy balance regulations in female Sprague-Dawley rats. The study lasted 8 weeks and the markers were assayed at day 8, 15, 29, 43 and 57. Results The results indicate that in the absence of hyperphagia, olanzapine chronic exposure induced weight gain from the beginning of the study. In the later time-point, increased adiposity was also observed. In the initial phase of the study, lipid profile was altered by an early increase in triglyceride level and highly elevated leptin level was observed. Clear bi-phasic time-dependent effect of olanzapine on leptin serum concentration was demonstrated. Olanzapine treatment did not lead to changes in serum levels of ghrelin, FGF-21 and pro-inflammatory markers IL-1a, IL-6 and TNF-alpha at any time-point of the study. Conclusion This study provides data suggesting early alteration in adipose tissue endocrine function as a factor involved in mechanisms underlying metabolic adverse effects of antipsychotics.
Abstract (in Czech)
Tato studie poskytuje data, která indikují časné alterace v endokrinní funkci tukové tkáně jako faktor zodpovědný za metabolické účinky atypických antipsychotik.
MUNI/A/1284/2015, internal MU codeName: Experimentální farmakologický vývoj v neuropsychiatrii a onkologii
Investor: Masaryk University, Grant Agency of Masaryk University, Category A
ROZV/24/LF/2016, internal MU codeName: LF - Příspěvek IP 2016
Investor: Ministry of Education, Youth and Sports of the CR, Development Programmes
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