| KNIGHT, Andrea, Pavel NĚMEC, Soňa BRETZOVÁ, Lucie VÁLKOVÁ, Markéta KOLMANOVÁ, Renáta VYTOPILOVÁ, Marek HAVELKA, Pavla VSIANSKA, Lucie RIHOVA, Marta KREJČÍ and Martin PISKÁČEK. Do human B-lymphocytes avoid aging until 60 years? Oncotarget. New York: Impact Journals, 2016, vol. 7, No 28, p. 42873-42880. ISSN 1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.10146. |
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@article{1350859,
author = {Knight, Andrea and Němec, Pavel and Bretzová, Soňa and Válková, Lucie and Kolmanová, Markéta and Vytopilová, Renáta and Havelka, Marek and Vsianska, Pavla and Rihova, Lucie and Krejčí, Marta and Piskáček, Martin},
article_location = {New York},
article_number = {28},
doi = {http://dx.doi.org/10.18632/oncotarget.10146},
keywords = {Aging; B cell; GEP; Gerotarget; IL7R; Naive B cells},
language = {eng},
issn = {1949-2553},
journal = {Oncotarget},
title = {Do human B-lymphocytes avoid aging until 60 years?},
volume = {7},
year = {2016}
}
TY - JOUR
ID - 1350859
AU - Knight, Andrea - Němec, Pavel - Bretzová, Soňa - Válková, Lucie - Kolmanová, Markéta - Vytopilová, Renáta - Havelka, Marek - Vsianska, Pavla - Rihova, Lucie - Krejčí, Marta - Piskáček, Martin
PY - 2016
TI - Do human B-lymphocytes avoid aging until 60 years?
JF - Oncotarget
VL - 7
IS - 28
SP - 42873-42880
EP - 42873-42880
PB - Impact Journals
SN - 19492553
KW - Aging
KW - B cell
KW - GEP
KW - Gerotarget
KW - IL7R
KW - Naive B cells
N2 - Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.
ER -
KNIGHT, Andrea, Pavel NĚMEC, Soňa BRETZOVÁ, Lucie VÁLKOVÁ, Markéta KOLMANOVÁ, Renáta VYTOPILOVÁ, Marek HAVELKA, Pavla VSIANSKA, Lucie RIHOVA, Marta KREJČÍ and Martin PISKÁČEK. Do human B-lymphocytes avoid aging until 60 years? \textit{Oncotarget}. New York: Impact Journals, 2016, vol.~7, No~28, p.~42873-42880. ISSN~1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.10146.
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