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@article{1350938, author = {Nešporová, Kristina and Sogorkova, Jana and Smejkalová, Daniela and Kulhanek, J. and HuertaandAngeles, G. and Kubala, Lukáš and Velebný, Vladimír}, article_location = {AMSTERDAM}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.ijpharm.2016.07.057}, keywords = {Polymeric micelle; Hyaluronan; Fatty acid; Albumin; Cell uptake; Stability}, language = {eng}, issn = {0378-5173}, journal = {International Journal of Pharmaceutics}, title = {Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles}, volume = {511}, year = {2016} }
TY - JOUR ID - 1350938 AU - Nešporová, Kristina - Sogorkova, Jana - Smejkalová, Daniela - Kulhanek, J. - Huerta-Angeles, G. - Kubala, Lukáš - Velebný, Vladimír PY - 2016 TI - Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles JF - International Journal of Pharmaceutics VL - 511 IS - 1 SP - 638-647 EP - 638-647 PB - ELSEVIER SCIENCE BV SN - 03785173 KW - Polymeric micelle KW - Hyaluronan KW - Fatty acid KW - Albumin KW - Cell uptake KW - Stability N2 - Polymeric micelles are attractive drug delivery systems for intravenously administered nonpolar drugs. Although physical parameters like size, shape and loading capacity are considered as the most important for their efficiency, here we demonstrate that the effects of serum protein interaction and characteristics of loaded compound cannot be neglected during the micelle development and design of experimental set up. Polymeric micelles prepared from amphiphilic hyaluronic acid grafted with short (hexanoic) and long fatty acids (oleic) were tested after loading with two different hydrophobic models, Nile red and curcumin. The composition of micelles affected mainly the loading capacity. Both encapsulated compounds behaved differently in the in vitro cell uptake, which was also influenced by serum concentration, where serum albumin was found to be the primary destabilizing component. This destabilization was found to be influenced by polymeric micelle concentration. Thus, the chemical structure of micelle, the properties of non-covalently loaded substance and serum albumin/polymeric micelle ratio modulate the in vitro intracellular uptake of drugs loaded in nanocarriers. (C) 2016 Published by Elsevier B.V. ER -
NEŠPOROVÁ, Kristina, Jana SOGORKOVA, Daniela SMEJKALOVÁ, J. KULHANEK, G. HUERTA-ANGELES, Lukáš KUBALA and Vladimír VELEBNÝ. Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles. \textit{International Journal of Pharmaceutics}. AMSTERDAM: ELSEVIER SCIENCE BV, 2016, vol.~511, No~1, p.~638-647. ISSN~0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2016.07.057.
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