TENORA, Lukáš, Stanislav MAN, Emilie VAN DEN BERGE and Milan POTÁČEK. The Synthesis of Two Regioisomeric Aldehydes with Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions. Synthesis. Thieme, 2016, vol. 48, No 15, p. 2429-2437. ISSN 0039-7881. Available from: https://dx.doi.org/10.1055/s-0035-1561428.
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Basic information
Original name The Synthesis of Two Regioisomeric Aldehydes with Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
Authors TENORA, Lukáš (203 Czech Republic, belonging to the institution), Stanislav MAN (203 Czech Republic, belonging to the institution), Emilie VAN DEN BERGE (56 Belgium) and Milan POTÁČEK (203 Czech Republic, guarantor, belonging to the institution).
Edition Synthesis, Thieme, 2016, 0039-7881.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.650
RIV identification code RIV/00216224:14310/16:00090538
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1055/s-0035-1561428
UT WoS 000381315900011
Keywords in English dipolar cycloadditions; benzothiophenes; polycycles; heterocycles; azomethine ylides;
Tags AKR, rivok
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 14/4/2017 15:43.
Abstract
The paper describes synthesis of two regioisomeric 2-amino-3-formyl and 3-amino-2-formyl substituted derivatives of tetrahydrobenzo[b] thiophene and their preparation for subsequent thermally-initiated reactions with secondary amines for generation of azomethine ylides; these azomethine ylides entered into intramolecular 1,3-dipolar cycloadditions. In this way, two series of new fused heterocyclic compounds were prepared, having three stereogenic centres. The compounds were identified and their structures determined.
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