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@article{1351693,
author = {Tichý, Michal and Knopfová, Lucia and Jarkovský, Jiří and Pekarčíková, Lucie and Veverková, Lenka and Vlček, Petr and Katolická, Jana and Čapov, Ivan and Hermanová, Markéta and Šmarda, Jan and Beneš, Petr},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s13277-016-4956-7},
keywords = {c-Myb; colorectal carcinoma; immunohistochemistry; metastases; mRNA},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma},
volume = {37},
year = {2016}
}
TY - JOUR
ID - 1351693
AU - Tichý, Michal - Knopfová, Lucia - Jarkovský, Jiří - Pekarčíková, Lucie - Veverková, Lenka - Vlček, Petr - Katolická, Jana - Čapov, Ivan - Hermanová, Markéta - Šmarda, Jan - Beneš, Petr
PY - 2016
TI - Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
JF - Tumor Biology
VL - 37
IS - 8
SP - 10723-10729
EP - 10723-10729
PB - Springer Netherlands
SN - 10104283
KW - c-Myb
KW - colorectal carcinoma
KW - immunohistochemistry
KW - metastases
KW - mRNA
N2 - The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis. The aim of this study was to examine the expression of c-Myb in CRC tissue samples both at the messenger RNA (mRNA) and protein levels and to evaluate their associations with clinicopathological characteristics in a group of 108 CRC patients. Statistically significant negative association was found between the frequency of the c-Myb-positive tumor cells assessed by immunohistochemistry and the presence of distant metastases but not tumor differentiation, tumor stage, lymph node involvement, vascular invasion, tumor localization, age, and gender of the patients. Although the c-Myb protein level in the tumor tissue correlated with its mRNA level, no significant association between MYB mRNA and any clinicopathological characteristics was observed. We conclude that albeit overexpression of c-Myb is considered as an important factor contributing to early phases of CRC tumorigenesis, it may later have negative effect on tumor cell dissemination as observed recently in breast cancer as well. Further studies are required to explain the role of c-Myb during formation of CRC distant metastases.
ER -
TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Lucie PEKARČÍKOVÁ, Lenka VEVERKOVÁ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA a Petr BENEŠ. Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma. \textit{Tumor Biology}. Springer Netherlands, roč.~37, č.~8, s.~10723-10729. ISSN~1010-4283. doi:10.1007/s13277-016-4956-7. 2016.
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