Overexpression of c-Myb is associated with suppression of
distant metastases in colorectal carcinoma

J 2016

Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Lucie PEKARČÍKOVÁ, Lenka VEVERKOVÁ et. al.

Basic information

Original name

Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma

Authors

TICHÝ, Michal (203 Czech Republic, belonging to the institution), Lucia KNOPFOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Lucie PEKARČÍKOVÁ (203 Czech Republic, belonging to the institution), Lenka VEVERKOVÁ (203 Czech Republic), Petr VLČEK (203 Czech Republic), Jana KATOLICKÁ (203 Czech Republic), Ivan ČAPOV (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Jan ŠMARDA (203 Czech Republic, belonging to the institution) and Petr BENEŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Tumor Biology, Springer Netherlands, 2016, 1010-4283

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.650

RIV identification code

RIV/00216224:14310/16:00088876

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s13277-016-4956-7

UT WoS

000382672900072

Keywords (in Czech)

c-Myb; kolorektální karcinom; imunohistochemie; metastázy; mRNA

Keywords in English

c-Myb; colorectal carcinoma; immunohistochemistry; metastases; mRNA

Abstract

V originále

The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis. The aim of this study was to examine the expression of c-Myb in CRC tissue samples both at the messenger RNA (mRNA) and protein levels and to evaluate their associations with clinicopathological characteristics in a group of 108 CRC patients. Statistically significant negative association was found between the frequency of the c-Myb-positive tumor cells assessed by immunohistochemistry and the presence of distant metastases but not tumor differentiation, tumor stage, lymph node involvement, vascular invasion, tumor localization, age, and gender of the patients. Although the c-Myb protein level in the tumor tissue correlated with its mRNA level, no significant association between MYB mRNA and any clinicopathological characteristics was observed. We conclude that albeit overexpression of c-Myb is considered as an important factor contributing to early phases of CRC tumorigenesis, it may later have negative effect on tumor cell dissemination as observed recently in breast cancer as well. Further studies are required to explain the role of c-Myb during formation of CRC distant metastases.

Links

NT13441, research and development project

Name: Exprese proteinů rodiny Myb v adenokarcinomech tlustého střeva a vztah k jejich metastatickému potenciálu

Citovat

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Lucie PEKARČÍKOVÁ, Lenka VEVERKOVÁ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA and Petr BENEŠ. Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma. Tumor Biology. Springer Netherlands, 2016, vol. 37, No 8, p. 10723-10729. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-016-4956-7.

@article{1351693,
   author = {Tichý, Michal and Knopfová, Lucia and Jarkovský, Jiří and Pekarčíková, Lucie and Veverková, Lenka and Vlček, Petr and Katolická, Jana and Čapov, Ivan and Hermanová, Markéta and Šmarda, Jan and Beneš, Petr},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s13277-016-4956-7},
   keywords = {c-Myb; colorectal carcinoma; immunohistochemistry; metastases; mRNA},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma},
   volume = {37},
   year = {2016}
}

TY  - JOUR
ID  - 1351693
AU  - Tichý, Michal - Knopfová, Lucia - Jarkovský, Jiří - Pekarčíková, Lucie - Veverková, Lenka - Vlček, Petr - Katolická, Jana - Čapov, Ivan - Hermanová, Markéta - Šmarda, Jan - Beneš, Petr
PY  - 2016
TI  - Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
JF  - Tumor Biology
VL  - 37
IS  - 8
SP  - 10723-10729
EP  - 10723-10729
PB  - Springer Netherlands
SN  - 10104283
KW  - c-Myb
KW  - colorectal carcinoma
KW  - immunohistochemistry
KW  - metastases
KW  - mRNA
N2  - The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis. The aim of this study was to examine the expression of c-Myb in CRC tissue samples both at the messenger RNA (mRNA) and protein levels and to evaluate their associations with clinicopathological characteristics in a group of 108 CRC patients. Statistically significant negative association was found between the frequency of the c-Myb-positive tumor cells assessed by immunohistochemistry and the presence of distant metastases but not tumor differentiation, tumor stage, lymph node involvement, vascular invasion, tumor localization, age, and gender of the patients. Although the c-Myb protein level in the tumor tissue correlated with its mRNA level, no significant association between MYB mRNA and any clinicopathological characteristics was observed. We conclude that albeit overexpression of c-Myb is considered as an important factor contributing to early phases of CRC tumorigenesis, it may later have negative effect on tumor cell dissemination as observed recently in breast cancer as well. Further studies are required to explain the role of c-Myb during formation of CRC distant metastases.
ER  -

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Lucie PEKARČÍKOVÁ, Lenka VEVERKOVÁ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA and Petr BENEŠ. Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma. \textit{Tumor Biology}. Springer Netherlands, 2016, vol.~37, No~8, p.~10723-10729. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-016-4956-7.

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