Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of
Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer
Cells

J 2015

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA et. al.

Basic information

Original name

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Authors

LAUKOVÁ, Jarmila (703 Slovakia, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), Jiřina HOFMANOVÁ (203 Czech Republic, belonging to the institution), Jana NEKVINDOVÁ (203 Czech Republic), P. SOVA (203 Czech Republic), M.P. MOYER (840 United States of America), J. EHRMANN (203 Czech Republic) and A.H. VACULOVA (203 Czech Republic, guarantor)

Edition

Plos one, San Francisco, Public Library of Science, 2015, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.057

RIV identification code

RIV/00216224:14310/15:00095868

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1371/journal.pone.0141020

UT WoS

000363249300023

Keywords in English

ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; ANTITUMOR EFFICACY; DNA-DAMAGE; IN-VITRO; CISPLATIN; LA-12; INHIBITION; GROWTH; ADAMANTYLAMINE

Abstract

V originále

We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.

Citovat

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN and A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. Plos one. San Francisco: Public Library of Science, 2015, vol. 10, No 10, p. nestránkováno, 20 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0141020.

@article{1351865,
   author = {Lauková, Jarmila and Kozubík, Alois and Hofmanová, Jiřina and Nekvindová, Jana and Sova, P. and Moyer, M.P. and Ehrmann, J. and Vaculova, A.H.},
   article_location = {San Francisco},
   article_number = {10},
   doi = {http://dx.doi.org/10.1371/journal.pone.0141020},
   keywords = {ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; ANTITUMOR EFFICACY; DNA-DAMAGE; IN-VITRO; CISPLATIN; LA-12; INHIBITION; GROWTH; ADAMANTYLAMINE},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells},
   url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1351865
AU  - Lauková, Jarmila - Kozubík, Alois - Hofmanová, Jiřina - Nekvindová, Jana - Sova, P. - Moyer, M.P. - Ehrmann, J. - Vaculova, A.H.
PY  - 2015
TI  - Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells
JF  - Plos one
VL  - 10
IS  - 10
SP  - nestránkováno
EP  - nestránkováno
PB  - Public Library of Science
SN  - 19326203
KW  - ACTIVATED-RECEPTOR-GAMMA
KW  - PPAR-GAMMA
KW  - ANTITUMOR EFFICACY
KW  - DNA-DAMAGE
KW  - IN-VITRO
KW  - CISPLATIN
KW  - LA-12
KW  - INHIBITION
KW  - GROWTH
KW  - ADAMANTYLAMINE
UR  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020
L2  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020
N2  - We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.
ER  -

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN and A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. \textit{Plos one}. San Francisco: Public Library of Science, 2015, vol.~10, No~10, p.~nestránkováno, 20 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0141020.

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