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@inproceedings{1353254,
author = {Hajnal, Matej and Šafránek, David and Demko, Martin and Pastva, Samuel and Krejčí, Pavel and Brim, Luboš},
address = {Neuveden},
booktitle = {Hybrid Systems Biology. HSB 2016},
doi = {http://dx.doi.org/10.1007/978-3-319-47151-8_4},
edition = {LNBI 9957},
editor = {Eugenio Cinquemani},
keywords = {signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Neuveden},
isbn = {978-3-319-47150-1},
pages = {57-66},
publisher = {Springer International Publishing},
title = {Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways},
year = {2016}
}
TY - JOUR
ID - 1353254
AU - Hajnal, Matej - Šafránek, David - Demko, Martin - Pastva, Samuel - Krejčí, Pavel - Brim, Luboš
PY - 2016
TI - Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways
PB - Springer International Publishing
CY - Neuveden
SN - 9783319471501
KW - signalling pathways
KW - systems biology
KW - parameter synthesis
KW - dynamical systems
KW - parameter estimation
N2 - Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.
ER -
HAJNAL, Matej, David ŠAFRÁNEK, Martin DEMKO, Samuel PASTVA, Pavel KREJČÍ and Luboš BRIM. Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways. In Eugenio Cinquemani. \textit{Hybrid Systems Biology. HSB 2016}. LNBI 9957. Neuveden: Springer International Publishing, 2016, p.~57-66. ISBN~978-3-319-47150-1. Available from: https://dx.doi.org/10.1007/978-3-319-47151-8\_{}4.
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