Detailed Information on Publication Record
2016
Intraepidermal nerve-fibre density as a biomarker of the course of neuropathy in patients with Type2 diabetes mellitus
DIVIŠOVÁ, Šárka, Eva VLČKOVÁ, Iva ŠROTOVÁ, Soňa KINCOVÁ, M. SKORNA et. al.Basic information
Original name
Intraepidermal nerve-fibre density as a biomarker of the course of neuropathy in patients with Type2 diabetes mellitus
Authors
DIVIŠOVÁ, Šárka (203 Czech Republic, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Iva ŠROTOVÁ (203 Czech Republic, belonging to the institution), Soňa KINCOVÁ (203 Czech Republic, belonging to the institution), M. SKORNA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Petr DUBOVÝ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)
Edition
Diabetic Medicine, Hoboken, Wiley-Blackwell, 2016, 0742-3071
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.054
RIV identification code
RIV/00216224:14110/16:00090718
Organization unit
Faculty of Medicine
UT WoS
000375119500011
Keywords in English
PERIPHERAL NEUROPATHY; NORMATIVE DATA; SKIN BIOPSY; DIAGNOSIS
Tags
International impact, Reviewed
Změněno: 6/9/2016 14:38, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Aims This paper aims to investigate whether intraepidermal nerve-fibre density (IENFD) may be used as a marker of the course of neuropathy in patients with Type2 diabetes mellitus. Methods Skin biopsies from the distal leg were serially evaluated in a group of 30 patients with Type2 diabetes mellitus (median age 60years, 17 men) with a short duration of diabetes (<3years) and good glucose control, and in 23 age- and sex-matched controls. The time intervals between biopsies were >2years (median 33.8months). Eighteen patients with Type2 diabetes mellitus had symptoms or signs of distal symmetrical diabetic polyneuropathy, 12 had no neuropathy. Results At first skin biopsy, IENFD was normal in all controls and in patients without neuropathy (mean 9.5 and 7.9fibres/mm, respectively) compared with abnormal IENFD in 77.8% in patients with polyneuropathy (mean 3.4fibres/mm). The annual rate of intraepidermal nerve-fibre (IENF) loss expressed as a percentage of the first IENFD value in patients with diabetic polyneuropathy was significantly higher [mean (se), 11.95 (3.82)%] compared with controls [1.92 (1.81)%, P<0.001] and similar to patients without polyneuropathy [12.16 (4.38)%]. The rate of IENF loss did not correlate with degree of glucose control. Conclusions The annual rate of IENF loss in patients with Type2 diabetes mellitus was several times higher than that of healthy participants, irrespective of the presence of signs or symptoms of diabetic polyneuropathy at initial evaluation. The change in IENFD is not linear and should be expressed as a proportion of initial IENFD to serve as a marker of the course of diabetic neuropathy. What's new? Intraepidermal nerve-fibre loss in patients with Type2 diabetes mellitus is not linear and should be expressed as a proportion of initial intraepidermal nerve-fibre density. Annual intraepidermal nerve-fibre loss as a marker of the progression of small-fibre neuropathy in patients with Type2 diabetes mellitus is several times higher compared with age-related intraepidermal nerve-fibre loss in age- and sex-matched people without diabetes. Change in intraepidermal nerve-fibre density in patients with Type2 diabetes mellitus of short duration and good glucose control is not dependent on the presence of neuropathy and degree of glucose control.
Links
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