Detailed Information on Publication Record
2016
Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Jan VOKURKA et. al.Basic information
Original name
Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
Authors
BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, guarantor, belonging to the institution), Denisa KAVŘÍKOVÁ (203 Czech Republic, belonging to the institution), Světlana LUČANOVÁ (203 Czech Republic, belonging to the institution), Hana POSKEROVÁ (203 Czech Republic, belonging to the institution), Jan VOKURKA (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution)
Edition
International Congress of Immunology 2016, Melbourne, 2016
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
Genetics and molecular biology
Country of publisher
Australia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.227
RIV identification code
RIV/00216224:14110/16:00088129
Organization unit
Faculty of Medicine
ISSN
Keywords in English
chemokine receptor; polymorphism; periodontitis; type 2 diabetes mellitus
Tags
Změněno: 20/12/2016 13:22, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Background: Periodontitis is a chronic inflammatory disease triggered by specific subgingival bacteria. Evidence suggests that diabetes mellitus (DM) may modulate periodontal tissue destruction, e.g. by reducing the polymorphonuclear leukocyte functions, including chemotaxis, adherence and phagocytosis. CXCR2 is a specific receptor for the interleukin-8 (IL-8) that is chemoattractant for neutrophils with an important role in the regulation of inflammatory response. Material and Methods: We analyzed CXCR2 +785C/T (rs2230054), +1208C/T (rs1126579) and +1440A/G (rs1126580) polymorphisms in patients with chronic periodontitis (CP) or CP with type 2 DM (T2DM+CP) and healthy controls and determined their associations with risk of diseases and occurrence of periodontal pathogens. Totally, 575 subjects (170 controls, 325 patients with CP and 80 subjects with T2DM+CP) were genotyped using methods based on polymerase chain reaction (PCR). Bacterial colonization (A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia, T. denticola, P. micros, F. nucleatum) was investigated by a DNA-microarray kit. Results: Although no differences in the allele/genotype frequencies between controls and patients with CP or T2DM+CP were found, TCA haplotype significantly increased the risk of T2DM+CP (P<0.05, OR=2.21, 95%CI:1.11-4.40 vs. controls and P<0.05, OR=1.52, 95%CI:1.08-2.16 vs. CP alone). A. actinomycetemcomitans occurred significantly more frequently in men patients with CP positive for T allele of CXCR2 +1208C/T variant (61.8% vs. 38.6%, P<0.05; OR=2.57, 95%CI=1.14-5.79) or positive for C allele of CXCR2 +785C/T polymorphism (61.8% vs. 40.9%, P<0.05; OR=2.33, 95%CI=1.04-5.25). Conclusion: Our findings demonstrated that CXCR2 gene variability may be one of the risk factors for T2DM+CP.
Links
| GB14-37368G, research and development project |
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| MUNI/A/1258/2015, interní kód MU |
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