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@proceedings{1353463,
author = {Bořilová Linhartová, Petra and Kavříková, Denisa and Lučanová, Světlana and Poskerová, Hana and Vokurka, Jan and Fassmann, Antonín and Izakovičová Hollá, Lydie},
booktitle = {International Congress of Immunology 2016, Melbourne},
doi = {http://dx.doi.org/10.1002/eji.201670200},
keywords = {chemokine receptor; polymorphism; periodontitis; type 2 diabetes mellitus},
language = {eng},
title = {Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population},
year = {2016}
}
TY - CONF
ID - 1353463
AU - Bořilová Linhartová, Petra - Kavříková, Denisa - Lučanová, Světlana - Poskerová, Hana - Vokurka, Jan - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY - 2016
TI - Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
KW - chemokine receptor
KW - polymorphism
KW - periodontitis
KW - type 2 diabetes mellitus
N2 - Background: Periodontitis is a chronic inflammatory disease triggered by specific subgingival bacteria. Evidence suggests that diabetes mellitus (DM) may modulate periodontal tissue destruction, e.g. by reducing the polymorphonuclear leukocyte functions, including chemotaxis, adherence and phagocytosis. CXCR2 is a specific receptor for the interleukin-8 (IL-8) that is chemoattractant for neutrophils with an important role in the regulation of inflammatory response. Material and Methods: We analyzed CXCR2 +785C/T (rs2230054), +1208C/T (rs1126579) and +1440A/G (rs1126580) polymorphisms in patients with chronic periodontitis (CP) or CP with type 2 DM (T2DM+CP) and healthy controls and determined their associations with risk of diseases and occurrence of periodontal pathogens. Totally, 575 subjects (170 controls, 325 patients with CP and 80 subjects with T2DM+CP) were genotyped using methods based on polymerase chain reaction (PCR). Bacterial colonization (A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia, T. denticola, P. micros, F. nucleatum) was investigated by a DNA-microarray kit. Results: Although no differences in the allele/genotype frequencies between controls and patients with CP or T2DM+CP were found, TCA haplotype significantly increased the risk of T2DM+CP (P<0.05, OR=2.21, 95%CI:1.11-4.40 vs. controls and P<0.05, OR=1.52, 95%CI:1.08-2.16 vs. CP alone). A. actinomycetemcomitans occurred significantly more frequently in men patients with CP positive for T allele of CXCR2 +1208C/T variant (61.8% vs. 38.6%, P<0.05; OR=2.57, 95%CI=1.14-5.79) or positive for C allele of CXCR2 +785C/T polymorphism (61.8% vs. 40.9%, P<0.05; OR=2.33, 95%CI=1.04-5.25). Conclusion: Our findings demonstrated that CXCR2 gene variability may be one of the risk factors for T2DM+CP.
ER -
BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Jan VOKURKA, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population. In \textit{International Congress of Immunology 2016, Melbourne}. 2016. ISSN~1521-4141. Available from: https://dx.doi.org/10.1002/eji.201670200.
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